ANI-7 is an aryl hydrocarbon receptor (AhR) activator that exhibits significant cytotoxicity against various cancer cell lines. It selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 activates the AhR pathway, leading to the induction of CYP1-metabolizing mono-oxygenases, DNA damage, kinase activation, and S-phase cell cycle arrest, ultimately resulting in cell death in sensitive breast cancer cell lines.
ANI-7 is an aryl hydrocarbon receptor (AhR) activator that exhibits significant cytotoxicity against various cancer cell lines. It selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 activates the AhR pathway, leading to the induction of CYP1-metabolizing mono-oxygenases, DNA damage, kinase activation, and S-phase cell cycle arrest, ultimately resulting in cell death in sensitive breast cancer cell lines.
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