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Anle138b-F105

p62/Sequestosome-1/SQSTM1 Ligand, Autophagic Degradation Inducer

Anle138b-F105 is an autophagic degradation inducer that targets p62/Sequestosome-1 (SQSTM1). By binding to the ZZ domain of p62, Anle138b-F105 facilitates its conformational activation and oligomerization, promoting interaction with LC3 and subsequent formation of autophagosomes. This compound enhances autophagic flux for the degradation of ubiquitin-conjugated aggregated proteins, making it a valuable tool for investigating neurodegenerative proteinopathies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inducer
CAS Number	2941386-44-1
Applications	p62/Sequestosome-1/SQSTM1 Ligand, Autophagic Degradation Inducer
Formula	C₃₆H₃₇FN₄O₅
Molecular Weight	624.70
SMILES	FC(C=C1)=CC=C1COC2=CC=CC(CNCCOCCOCCNC3=CC(C4=CC(C5=CC=C(OCO6)C6=C5)=NN4)=CC=C3)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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Anle138b-F105

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Anle138b-F105 5 mg