Fig. 1 · Structure
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Anti-inflammatory agent 49
Drp1-Fis1 inhibtor
Anti-inflammatory agent 49 is a selective inhibitor of the Drp1-Fis1 interaction, targeting mitochondrial dynamics. It effectively reduces FIS1-mediated mitochondrial dysfunction, making it a valuable tool in studies of cellular metabolism and inflammatory responses. With an IC50 of 270 nM for inhibiting GTPase activity in vitro, this compound is suitable for investigating the roles of mitochondrial dynamics in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 851471-44-8 |
| Applications | Drp1-Fis1 inhibtor |
| Formula | C21H22N8O3S |
| Molecular Weight | 466.52 |
| SMILES | O=C1NC(N(CC2=CC=CC=C2)C(N)=C1N(C)C(CSC3=NN4C(C)=CC(C)=NC4=N3)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.