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Anti-osteoporosis agent-8

RANKL Inhibitor

Anti-osteoporosis agent-8 is a RANKL inhibitor that effectively suppresses RANKL-induced osteoclastogenesis and differentiation, demonstrating an IC50 of 2.41 μM in RAW264.7 cells. This compound has shown potential in mitigating bone loss in ovariectomized (OVX) mouse models, highlighting its significance in osteoporosis research and therapeutic applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3036050-96-8
Applications	RANKL Inhibitor
Formula	C₁₈H₁₉F₃N₂O₂Se
Molecular Weight	431.31
SMILES	O=C(NC1=CC=NC=C1)C([Se]C2=CC=CC=C2)C(C)(OCC(F)(F)F)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.