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Anticancer agent 306

Anticancer Agent

Anticancer Agent 306 is a spiro tetramic acid derivative that serves as an inhibitor of MMP1, MMP7, and PLK1. It demonstrates potent antiproliferative effects against H1299, RKO, and MCF-7 cell lines, with IC50 values of 19.25 μM, 3.29 μM, and 102.36 μM, respectively. This compound induces cell cycle arrest by up-regulating p21 while down-regulating CCND1 and CCNB1, and also promotes apoptosis by modulating Bcl-2 and Bax expression. Additionally, Anticancer Agent 306 inhibits tumor invasion and metastasis through the down-regulation of MMP1 and MMP7. It is applicable in cancer research focused on lung, colorectal, and breast cancers.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3043892-01-6
Applications	Anticancer Agent
Formula	C₁₉H₂₁Cl₂NO₃
Molecular Weight	382.28
SMILES	ClC1=CC(Cl)=C(C2=C(OC(CC(C)C)=O)C3(CCCC3)NC2=O)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.