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Antidepressant agent 8

GluN1/2A Antagonist

Antidepressant agent 8 is a selective antagonist of the NMDA receptor subunits GluN1/2A, demonstrating an IC50 of 2.94 μmol/L. This compound exhibits significant antidepressant-like effects in a hydrocortisone-induced zebrafish model of depression. Additionally, its ability to cross the blood-brain barrier makes it a valuable tool for investigating potential therapeutic strategies in neuropsychiatric disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	3066104-04-6
Applications	GluN1/2A Antagonist
Formula	C₁₈H₂₃FN₄OS₂
Molecular Weight	394.53
SMILES	FC1=CC(CNC2=NN=C(SCC(NCC3CCCCC3)=O)S2)=CC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.