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Antifolate agent 1

Antifolate

Antifolate Agent 1 is a 6-substituted pyrrolopyrimidine antifolate designed to target antifolate mechanisms. This compound exhibits no activity against cells expressing folate receptors FRα and FRβ, nor does it inhibit GARFTase, making it an appropriate negative control in the development of folate receptor-targeted antifolates. Its distinct profile makes Antifolate Agent 1 a valuable tool for researchers investigating antifolate therapies and receptor-specific interactions.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	518063-75-7
Applications	Antifolate
Formula	C₁₉H₁₉N₅O₆
Molecular Weight	413.38
SMILES	O=C1C2=C(NC(N)=N1)NC(CC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.