Fig. 1 · Structure
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Antifolate C1
GARFTase Inhibitor
Antifolate C1 is a specific inhibitor of GARFTase, targeting the de novo purine biosynthesis pathway. It effectively impairs cell proliferation by disrupting nucleotide synthesis, making it a valuable tool in cancer research and studies exploring cellular growth regulation. Its mechanism of action highlights its potential utility in investigating purine metabolism in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 136784-51-5 |
| Applications | GARFTase Inhibitor |
| Formula | C19H21N5O6S |
| Molecular Weight | 447.46 |
| Synonyms | AGF 94 |
| SMILES | O=C1C2=C(NC(N)=N1)NC(CCCC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)S3)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.