Fig. 1 · Structure
Documents & Downloads
Antifolate C2
Antipurine Antifolate Drug
Antifolate C2 is an antipurine antifolate drug that selectively inhibits the proton-coupled folate transporter (PCFT). This compound exerts its biological activity by targeting glycinamide ribonucleotide formyltransferase (GARFTase), disrupting deoxypurine nucleotide biosynthesis and subsequently inhibiting the proliferation of non-squamous non-small cell lung cancer (NS-NSCLC) cells. Antifolate C2 is particularly suitable for research applications focused on NS-NSCLC, especially for patients who exhibit resistance to traditional treatments such as Pemetrexed.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1286279-90-0 |
| Applications | Antipurine Antifolate Drug |
| Formula | C19H21N5O6S |
| Molecular Weight | 447.46 |
| SMILES | O=C1C2=C(NC(N)=N1)NC(CCCC3=CC(C(N[C@H](C(O)=O)CCC(O)=O)=O)=CS3)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.