Fig. 1 · Structure
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Antiparasitic agent-30
TbrAK Activator
Antiparasitic agent-30 is a potent modulator of adenosine kinase TbrAK, designed to enhance its activity against Trypanosoma brucei rhodesiense, which is responsible for acute African human trypanosomiasis. This agent demonstrates significant inhibitory activity, exhibiting an EC50 of 38 nM and a binding affinity ranging from 75 nM to 497 nM. By overcoming intrinsic substrate inhibition and hyperactivating TbrAK, Antiparasitic agent-30 offers valuable insights for researchers studying the pathology and treatment of sleeping sickness.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 671754-20-4 |
| Applications | TbrAK Activator |
| Formula | C19H19N3O2 |
| Molecular Weight | 321.37 |
| SMILES | C1(C2=CC=C(OC3=CC=CC=C3)C=C2)=CC(N4CCOCC4)=NN1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.