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Antiproliferative agent-53-d3

Name: Antiproliferative agent-53-d3
Brand: Adooq Bioscience
SKU: A69849
Availability: OutOfStock

Cat. No. A69849 CAS 2923508-77-2

CYP Inhibitor

Antiproliferative agent-53-d3 is a selective inhibitor of cytochrome P450 enzymes CYP2C19 and CYP2C9, exhibiting IC50 values of 0.77 µM and 3.1 µM, respectively. This compound effectively inhibits theta-mediated end joining (TMEJ) in HEK293 cells, with an IC50 of 0.14 µM, and demonstrates significant antiproliferative effects on DNA repair-compromised BRCA2-/- DLD-1 cells, showing an IC50 of 8.1 µM. In addition, antiproliferative agent-53-d3 displays favorable pharmacokinetic properties in CD-1 mice, making it a valuable reagent for studies in cancer research and drug metabolism.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2923508-77-2
Applications	CYP Inhibitor
Formula	C₂₀H₁₄D₃ClF₄N₄O₂
Molecular Weight	459.84
SMILES	[2H]C([2H])([2H])N(C1=CC(Cl)=C(C=C1)F)C([C@H]2N(C3=C(C(C(F)(F)F)=CC(C)=N3)C#N)C[C@H]2CO)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.