Fig. 1 · Structure
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Antiproliferative agent-61
Apoptosi
Antiproliferative agent-61 is a synthetic β-carlinyl chalcone that targets apoptosis pathways to exhibit significant antiproliferative effects. This compound demonstrates robust activity across various solid tumor cell lines, particularly in breast cancer models, with IC50 values of 2.25 and 3.29 μM in the MCF-7 cell line. Antiproliferative agent-61 effectively induces DNA fragmentation and apoptosis, while also inhibiting the MDM2-p53 interaction and promoting MDM2 degradation. This makes it a valuable reagent for cancer research focused on therapeutic strategies targeting apoptosis and tumor growth suppression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1613078-24-2 |
| Applications | Apoptosi |
| Formula | C22H18N2O3 |
| Molecular Weight | 358.39 |
| SMILES | O=C(/C=C/C1=NC=CC2=C1NC3=C2C=CC=C3)C4=CC=C(C(OC)=C4)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.