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Antitrypanosomal agent 26

TAO Inhibitor

Antitrypanosomal agent 26 is an allosteric inhibitor of trypanosome alternative oxidase (TAO). It demonstrates potent activity against African animal trypanosomes, including Trypanosoma brucei, with an IC50 value of 1.3 nM for recombinant TAO. By disrupting the mitochondrial electron transport chain, Antitrypanosomal agent 26 inhibits glucose-dependent respiration in trypanosomes. This compound is valuable for research into African animal trypanosomiasis, particularly bovine trypanosomiasis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2601665-22-7
Applications	TAO Inhibitor
Formula	C₃₉H₄₉BrNO₃P
Molecular Weight	690.69
SMILES	O=C(OCCCCCCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=NC=CC=C3)C4=CC=C(O)C=C4C.[Br-]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.