Fig. 1 · Structure
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Antitumor agent-136
Antitumor agent
Antitumor Agent-136 is a potent broad-spectrum antitumor agent that functions as a NAMPT inhibitor, demonstrating an IC50 value of 9.5 nM. This compound effectively reduces both intracellular and extracellular levels of NAMPT protein via the ubiquitin-proteasome pathway, resulting in significant tumor inhibition. It is suitable for research applications focused on cancer biology and the exploration of NAMPT-related therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2484876-94-8 |
| Applications | Antitumor agent |
| Formula | C58H76N10O11S3 |
| Molecular Weight | 1185.48 |
| SMILES | O=C(C1=CC=C(C=C1)CN2CCN(CC2)S(=O)(C3=CC=C(C=C3)NC(NCC4=CN=CC=C4)=S)=O)NCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.