Fig. 1 · Structure
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Antitumor agent-19
Antitumor Agent
Antitumor Agent-19 is an antitumor compound that specifically targets tumor-associated macrophages (TAMs), serving as a powerful modulator of their activity. This reagent effectively elevates TNF-alpha levels in tumor cells, demonstrating EC50 values of 17.18 μM in RAW 264.7 cells and 18.87 μM in bone marrow-derived macrophages (BMDM). Antitumor Agent-19 is suitable for research applications focused on immunology and cancer biology, particularly in exploring the role of TAMs in tumor progression and therapeutic response.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2379727-90-7 |
| Applications | Antitumor Agent |
| Formula | C24H21ClF3N5O |
| Molecular Weight | 487.90 |
| SMILES | O=C(NC1CCC(NC2=C3C(C4=CN(C)N=C4)=CC=C2)=C3C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.