Fig. 1 · Structure
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Antitumor agent-60
Antitumor Agent
Antitumor agent-60 is a potent inhibitor of the RAS-RAF signaling pathway, specifically binding to CRAF with a Kd value of 3.93 μM. This compound induces apoptosis by arresting the cell cycle at the G2/M phase and elevates p53 levels and reactive oxygen species (ROS) within cells. Additionally, antitumor agent-60 induces morphological changes, including oval and irregular nuclei in cancer cells. In vivo studies demonstrate its ability to suppress tumor growth in an A549 xenograft model, underscoring its potential for cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 865784-65-2 |
| Applications | Antitumor Agent |
| Formula | C24H28O10S |
| Molecular Weight | 508.54 |
| SMILES | COC1=CC(OC)=C(C(OC)=C1)/C=C/S(=O)(CC2=CC=C(C(OC(CCCC(O)=O)=O)=C2)OC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.