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Antitumor agent-61

Antitumor Agent

Antitumor agent-61 is a derivative of Irinotecan with notable antitumor properties. It demonstrates significant cytotoxic activity, exhibiting IC50 values of 0.92, 1.39, 1.75, 2.20, 3.05, and 3.23 μM against various human cancer cell lines, including SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549, and MG-63. The compound promotes apoptosis in SK-OV-3 cells through mitochondrial pathways, positioning it as a valuable candidate for cancer research and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2408917-12-2
Applications	Antitumor Agent
Formula	C₅₄H₆₃FN₅O₁₀P
Molecular Weight	992.08
SMILES	O=C(N1CCC(CC1)N2CCCCC2)OC3=CC4=C(CC)C5=C(C6=CC7=C(COC(C7(CC)OC(CCCC8=CC=C(NC(P(OCC)(OCC)=O)C9=CC=C(C=C9)F)C=C8)=O)=O)C(N6C5)=O)N=C4C=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.