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Antitumor agent-69

Antitumor Agent

Antitumor Agent-69 is a potent inhibitor of the protein-protein interactions between DOT1L and MLL-AF9/MLL-ENL, demonstrating inhibition constants (Kis) of 9 nM and 109 nM for AF9 and ENL, respectively. This compound exhibits significant anticancer activity, making it a valuable tool for research in tumor biology and therapeutic development. Its selective inhibition of these interactions suggests potential applications in studying leukemia and other malignancies driven by MLL fusion proteins.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2417651-42-2
Applications	Antitumor Agent
Formula	C₄₃H₆₂N₈O₅
Molecular Weight	771.00
SMILES	O=C([C@H]1N(CCC1)C(CCC(C)C)=O)N[C@@H](C(C)C)C(N[C@@H](CNC)C(N[C@@H](CC2CCCC2)C(N[C@H](C3=NC4=CC=CC(C5=CC=CC=C5)=C4N3)C)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.