AP 811 is a selective antagonist of the natriuretic peptide clearance receptor (NPR3) with a binding affinity (Ki) of 0.48 nM. It demonstrates over 20,000-fold selectivity for NPR3 compared to NPR1. AP 811 effectively inhibits atrial natriuretic peptide (ANP)-induced stimulation of transport pumps, making it a valuable tool for research into cardiovascular and kidney function regulation.
AP 811 is a selective antagonist of the natriuretic peptide clearance receptor (NPR3) with a binding affinity (Ki) of 0.48 nM. It demonstrates over 20,000-fold selectivity for NPR3 compared to NPR1. AP 811 effectively inhibits atrial natriuretic peptide (ANP)-induced stimulation of transport pumps, making it a valuable tool for research into cardiovascular and kidney function regulation.
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