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AP23848

ATP-dependent Kinase Inhibitors

AP23848 is an ATP-dependent kinase inhibitor that specifically targets the activation loop mutation of the Kit protein. This compound demonstrates significant anti-tumor activity by inhibiting phosphorylation associated with activated Kit mutations, effectively reducing tumor growth in preclinical mouse models. AP23848 is particularly applicable in research related to diseases characterized by the D816V mutation, including systemic mastocytosis (SM) and acute myeloid leukemia (AML).

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	834894-21-2
Applications	ATP-dependent Kinase Inhibitors
Formula	C₃₀H₃₈N₅O₂P
Molecular Weight	531.63
SMILES	OC1=CC=CC(CCN2C3=NC(C4CCCC4)=NC(NC5=CC=C(P(CCC)(CCC)=O)C=C5)=C3N=C2)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.