Fig. 1 · Structure
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Apcin-A monohydrochloride
APC Inhibitor
Apcin-A monohydrochloride is a selective inhibitor of the anaphase-promoting complex (APC) that effectively interacts with Cdc20, impeding the ubiquitination of its substrates. This compound is valuable for studying the regulatory mechanisms of protein degradation in mitosis and is applicable in research involving cell cycle regulation. Additionally, Apcin-A monohydrochloride can be utilized in the synthesis of the PROTAC CP5V, facilitating advanced studies in targeted protein degradation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1683535-53-6 |
| Applications | APC Inhibitor |
| Formula | C10H15Cl4N5O2 |
| Molecular Weight | 379.07 |
| SMILES | O=C(NC(C(Cl)(Cl)Cl)NC1=NC=CC=N1)OCCCN.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.