Fig. 1 · Structure
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APE1-IN-1
APE1 Inhibitor
APE1-IN-1 is a selective inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1), known for its ability to penetrate the blood-brain barrier. With an IC50 value of 2 μM, this compound enhances the cytotoxic effects of alkylating agents such as Methylmethane sulfonate and Temozolomide in cancer cells. APE1-IN-1 is valuable for research into cancer therapeutics and the roles of DNA repair mechanisms in tumor progression and treatment resistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 524708-03-0 |
| Applications | APE1 Inhibitor |
| Formula | C19H21N3OS2 |
| Molecular Weight | 371.53 |
| SMILES | CC(NC(S1)=C(C2=NC3=CC=CC=C3S2)C4=C1CN(C(C)C)CC4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.