Fig. 1 · Structure
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APE1-IN-2
APE1 Inhibitor
APE1-IN-2 is a potent inhibitor of apurinic/apyrimidinic endonuclease 1 (APE1), a key player in the base excision repair (BER) pathway. This compound demonstrates significant anticancer activity by facilitating intracellular accumulation of platinum and triggering DNA damage response mechanisms, leading to apoptosis. APE1-IN-2 is valuable for research applications focused on cancer biology and the modulation of DNA repair processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2923433-95-6 |
| Applications | APE1 Inhibitor |
| Formula | C9H12Cl2N4O5Pt |
| Molecular Weight | 522.21 |
| SMILES | O[Pt](Cl)(Cl)(OC(C1=CC2=CC=CC([N+]([O-])=O)=C2N1)=O)([NH3])[NH3] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.