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APL-4098

GCN2 Inhibitor

APL-4098 is a selective, orally active inhibitor of GCN2, exhibiting ATP-competitive inhibition with a Ki of 4.39 nM and a Kd of 2.9 nM. This compound effectively reduces eIF2α phosphorylation and ATF4 expression, leading to impaired mitochondrial function and cytotoxicity in primary acute myeloid leukemia cells. APL-4098 is valuable for research focused on the pathophysiology and treatment of acute myeloid leukemia.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2752441-61-3
Applications	GCN2 Inhibitor
Formula	C₁₇H₁₂ClFN₆O₃S
Molecular Weight	434.83
SMILES	COC1=C(C=C(C=N1)Cl)S(=O)(NC2=NC=CC(C#CC3=CN=C(N=C3)N)=C2F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.