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APL-5125

CK2α Inhibitor

APL-5125 is a selective ATP-competitive inhibitor of CK2α, displaying a potent inhibitory capacity with an IC50 of 0.348 nM and a Ki of 0.095 nM. It binds to CK2α in a bivalent manner by targeting both the ATP-binding site and the αD pocket. APL-5125 demonstrates significant antitumor activity, making it a valuable tool for cancer research, particularly in exploring therapeutic strategies for conditions such as colon cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2830619-57-1
Applications	CK2α Inhibitor
Formula	C₂₇H₂₄F₅N₃O₅
Molecular Weight	565.49
SMILES	O=C(O)C1=CC2=NC(OCCOCCCCNCC3=CC(F)=C(OC(F)(F)F)C(F)=C3)=C4C=CN=CC4=C2C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.