Fig. 1 · Structure
Documents & Downloads
APN-PEG5-VC-PAB-MMAE
Drug-Linker Conjugate
APN-PEG5-VC-PAB-MMAE is a drug-linker conjugate designed for targeted delivery in cancer therapy, specifically targeting CD71. This compound utilizes a valine-citrulline linkage to release the cytotoxic agent MMAE upon internalization, providing an effective approach to enhance therapeutic efficacy while minimizing systemic toxicity. Its application includes research into antibody-drug conjugates and cancer treatment strategies, particularly in optimizing delivery mechanisms to tumor sites.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2252392-31-5 |
| Applications | Drug-Linker Conjugate |
| Formula | C81H120N14O18 |
| Molecular Weight | 1577.90 |
| SMILES | O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCC(N=N4)=CN4C5=CC=C(C#CC#N)C=C5)=O)C(C)C)=O)CCCNC(N)=O)=O)=O)=O)=O)=O)OC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.