(+)-Apogossypol

Catalog No.: A16316

Bcl-2 family inhibitor

(+)-Apogossypol

(+)-Apogossypol Chemical Structure

CAS NO. 66389-74-0

(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM.

Availability: In stock

Package Price Qty
5 mg
$320.00
10 mg
$580.00
50 mg
$1,600.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.62 mL 108.1 mL 216.2 mL
0.5 mM 4.32 mL 21.62 mL 43.24 mL
1 mM 2.16 mL 10.81 mL 21.62 mL
5 mM 0.43 mL 2.16 mL 4.32 mL

*The above data is based on the productmolecular weight 462.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A16316
Actions Inhibitor
M. Wt 462.53
Formula C28H30O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 66389-74-0
Synonyms Apogossypol, NSC736630
SMILES CC(C=C1C(C(C)C)=C(O)C(O)=CC1=C2O)=[[email protected]]2[[email protected]@]3=C(C)C=C4C(C=C(O)C(O)=C4C(C)C)=C3O

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