(+)-Apogossypol

Catalog No.: A16316

Bcl-2 family inhibitor

(+)-Apogossypol

(+)-Apogossypol Chemical Structure

CAS NO. 66389-74-0

(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM.

Availability: In stock

Package Price Qty
5 mg
$320.00
10 mg
$580.00
50 mg
$1,600.00
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Biological Activity

(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.62 mL 108.1 mL 216.2 mL
0.5 mM 4.32 mL 21.62 mL 43.24 mL
1 mM 2.16 mL 10.81 mL 21.62 mL
5 mM 0.43 mL 2.16 mL 4.32 mL

*The above data is based on the productmolecular weight 462.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16316
Actions Inhibitor
CAS No. 66389-74-0
Formula C28H30O6
M. Wt 462.53
Solubility DMSO
Purity >98%
Synonyms Apogossypol, NSC736630
SMILES CC(C=C1C(C(C)C)=C(O)C(O)=CC1=C2O)=[[email protected]]2[[email protected]@]3=C(C)C=C4C(C=C(O)C(O)=C4C(C)C)=C3O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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