Fig. 1 · Structure
Documents & Downloads
Apomine
HMGR Inhibitor
Apomine is a potent inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), effectively targeting the mevalonate/isoprenoid pathway involved in cholesterol biosynthesis. This compound exhibits significant antineoplastic activity, demonstrating the ability to inhibit the growth of a range of cancer cell types, including lung, colon, breast, and skin cancers. Furthermore, Apomine induces apoptosis in various tumor cell lines, making it a valuable tool for research in cancer biology and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 126411-13-0 |
| Applications | HMGR Inhibitor |
| Formula | C28H52O7P2 |
| Molecular Weight | 562.66 |
| Synonyms | SR-45023A; SR 9223i; SK&F-99085 |
| SMILES | CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CC(P(OC(C)C)(OC(C)C)=O)P(OC(C)C)(OC(C)C)=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.