Bcl-2 Family

Cat. No.

A10022

CAS No.

923564-51-6

Navitoclax (ABT-263)

Synonyms: ABT263

ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). it maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.

Cat. No.

A10255

CAS No.

852808-04-9

ABT-737

ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to

Cat. No.

A12500

CAS No.

1257044-40-8

Venetoclax (ABT-199)

Synonyms: ABT199; GDC-0199; RG7601

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.

Cat. No.

A10665

CAS No.

803712-79-0

Obatoclax mesylate (GX15-070)

Synonyms: GX15-070

Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).

Cat. No.

A13652

CAS No.

297730-17-7

AVN-944

Synonyms: VX-944

AVN-944 (also known as VX-944) serves as an effective oral inhibitor, specifically targeting and inhibiting IMPDH (inosine monophosphate dehydrogenase). This enzyme plays a crucial role as a rate-limiting factor in the synthesis of guanine nucleotides from scratch. Additionally, AVN-944 acts against the synthesis of RNA in arenaviruses, effectively preventing arenavirus infections. Demonstrating a wide spectrum of anti-cancer properties, AVN-944 is utilized in research related to multiple myeloma (MM) and acute myeloid leukemia (AML).

Cat. No.

A16112

CAS No.

1235034-55-5

A-1155463

A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = 1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)

Cat. No.

A11988

CAS No.

2752-65-0

Gambogic acid

Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.

Cat. No.

A12823

CAS No.

1228108-65-3

Sabutoclax

Synonyms: BI-97C1

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

Cat. No.

A13580

CAS No.

383860-03-5

Bcl-2 Inhibitor

Synonyms: TW-37

Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively).

Cat. No.

A15335

CAS No.

335165-68-9

Bax channel blocker

Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 μM).

Cat. No.

A15545

CAS No.

1668553-26-1

A-1210477

A-1210477 is a potent and selective MCL-1 inhibitor. A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines.

Cat. No.

A16315

CAS No.

509102-00-5

MIM1

Synonyms: Inhibitor of Mcl-1

MIM1 is a selective small molecule inhibitor of Mcl-1(IC50= 4.8 μM) that overcomes Mcl-1-dependent leukemia cell survival.

Cat. No.

A10955

CAS No.

877877-35-5

TW-37

TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.

Cat. No.

A11448

CAS No.

65673-63-4

HA14-1

HA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2.

Cat. No.

A12743

CAS No.

1391108-10-3

BM-1074

BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of

Cat. No.

A13005

CAS No.

1431866-33-9

WEHI539

WEHI539 is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.

Cat. No.

A13327

CAS No.

2070018-33-4

WEHI-539 hydrochloride

Synonyms: WEHI539 HCl

WEHI-539 hydrochloride is a small-molecule inhibitor of BCL-xL with IC50 value of 1.1 nM.

Cat. No.

A13578

CAS No.

866541-93-7

AT101 acetic acid

Synonyms: AT-101

AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID

Cat. No.

A14222

CAS No.

518303-20-3

UMI-77

Synonyms: UMI 77,UMI77

UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.

Cat. No.

A14795

CAS No.

12542-36-8

Acetate gossypol

Synonyms: Gossypol-acetic acid

Acetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic.

Cat. No.

A15004

CAS No.

90141-22-3

(R)-(-)-Gossypol (AT-101)

Synonyms: R-(-)-gossypol acetic acid; AT 101

AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM.

Cat. No.

A15336

CAS No.

579492-83-4

Bax inhibitor peptide P5

Bax inhibitor peptide P5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.

Cat. No.

A15337

CAS No.

579492-81-2

Bax inhibitor peptide V5

Bax inhibitor peptide V5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.

Cat. No.

A15338

CAS No.

1315378-74-5

Bax inhibitor peptide, negative control

Bax inhibitor peptide, negative control, negative control peptide for the Bax inhibitor peptides V5 and P5 , which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.

Cat. No.

A16190

CAS No.

1430844-80-6

A-1331852

A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML.