ABT-737

Name: ABT-737
SKU: A10255
Price: 50 USD
Rating: 5 (15 reviews)

Catalog No.: A10255

Bcl-2 Inhibitor

Adooq's ABT-737 has been cited by 15 publications

ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).

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Grouped product items
Product Name	Price	Stock
ABT-737 5mg	$50.00	In stock
ABT-737 10mg	$90.00	In stock
ABT-737 50mg	$300.00	In stock
ABT-737 100mg	$480.00	In stock
*ABT-737 10mM 1mL in DMSO**	$80.00	In stock
Bulk Size	Bulk Discount

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Important Notice: For research use only. We do not sell to patients.

Data Sheet

SDS

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Adooq Products cited in reputable paper

Adooq's ABT-737 has been cited by 15 publications

Jung Mo Lee, .et al. , Yonsei Med J, 2022, Jan;63(1):16-25 PMID: 34913280

AidaVarela-Moreira, .et al. , Int J Pharm, 2022, Apr 25;618:121638 PMID: 35257802

Daniel F R Boehmer, .et al. , Sci Immunol, 2021, Jul 16;6(61) PMID: 34272227

Shivani Arora, .et al. , Med, 2021, 2,1-13

Ying Ji, .et al. , Nat Commun, 2020, Aug 25;11(1):4249 PMID: 32843618

Birgit Ritschka, .et al. , Genes Dev, 2020, Apr 1;34(7-8):489-494 PMID: 32139422

Hiroki Akiyama, .et al. , Cancers, 2020, 12 (2) PMID: 32050632

Hsu CC, .et al. , Arch Oral Biol, 2020, Mar;111:104653 PMID: 31935534

Gupta VK, .et al. , Apoptosis, 2020, Feb;25(1-2):135-150 PMID: 31867678

Meikle V, .et al. , Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480

Chauhan D, .et al. , Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805

Jose Mario Gonzalez-Meljem, .et al. , Nat Commun, 2017, 8: 1819 PMID: 29180744

Zhang C, .et al. , J Biol Chem, 2017, Sep 8;292(36):15105-15120 PMID: 28673964

Eun Young Kim, .et al. , Neoplasia, 2017, Apr; 19(4): 354-363 PMID: 28319809

Masayoshi Toge, .et al. , Int J Oncol., 2015, Apr;46(4):1844-8 PMID: 25647738

Biological Activity

Discription

ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).

Targets

Target	Value

Product Information

Catalog Num	A10255
Formula	C42H45ClN6O5S2
Molecular Weight	813.4
CAS Number	852808-04-9
SMILES	CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	92 mg/mL (113.1 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2%DMSO+40%PEG300+5%Tween80+53%ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.29 mL	61.47 mL	122.94 mL
0.5 mM	2.46 mL	12.29 mL	24.59 mL
1 mM	1.23 mL	6.15 mL	12.29 mL
5 mM	0.25 mL	1.23 mL	2.46 mL

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