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ABT-737

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Bcl-2 Inhibitor

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Catalog No. A10255

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ABT-737 5mg A10255-5

Regular Price: $50.00

Special Price: $45.00

ABT-737 10mg A10255-10

Regular Price: $90.00

Special Price: $81.00

ABT-737 50mg A10255-50

Regular Price: $300.00

Special Price: $270.00

ABT-737 100mg A10255-100

Regular Price: $480.00

Special Price: $432.00

ABT-737 10mM * 1mL in DMSO A10255-10mM-D

Regular Price: $80.00

Special Price: $72.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).

ABT-737

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Publications citing Adooq Products
ABT-737 Citations (6)
  • Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
  • Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
  • Jose Mario Gonzalez-Meljem, .et al. Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma, Nat Commun, 2017, 8: 1819 PMID: 29180744
  • Zhang C, .et al. Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response, J Biol Chem, 2017, Sep 8;292(36):15105-15120 PMID: 28673964
  • Eun Young Kim, .et al. ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer, Neoplasia, 2017, Apr; 19(4): 354-363 PMID: 28319809
  • Masayoshi Toge, .et al. Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer., Int J Oncol., 2015, Apr;46(4):1844-8 PMID: 25647738

Chemical Information

Catalog Num A10255
Actions Inhibitor
M. Wt 813.4
Formula C42H45ClN6O5S2
Solubility DMSO>163mg/mL Water<1mg/mL Ethanol<1mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 852808-04-9
Synonyms N/A
SMILES CN(C)CC[[email protected]](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]

Biological Activity

Description
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).
Targets
Target Value
Bcl-2EC50:30.3nM
Bcl-xLEC50:78.7nM
Bcl-wEC50:197.8nM
Bcl-BEC50:1.82 uM
Bfl-1EC50>10 uM
Mcl-1EC50>10 uM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (122.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.29 mL 61.47 mL 122.94mL
0.5 mM 2.46 mL 12.29 mL 24.59 mL
1 mM 1.23 mL 6.15 mL 12.29 mL
5 mM 0.25 mL 1.23 mL 2.46 mL

*The above data is based on the productmolecular weight 813.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10255 ABT-737 <1 mg/mL 163 mg/mL <1 mg/mL
A10022 ABT-263 (Navitoclax) <1 mg/mL 195 mg/mL <1 mg/mL
A10665 Obatoclax mesylate (GX15-070) <1 mg/mL 83 mg/mL <1 mg/mL
A10955 TW-37 <1 mg/mL 115 mg/mL 4 mg/mL
A10984 VX-765 <1 mg/mL 102 mg/mL 102 mg/mL
A11090 PAC-1 <1 mg/mL 78 mg/mL 16 mg/mL
A10491 JNJ 26854165 <1 mg/mL 66 mg/mL 2 mg/mL
A11931 RITA (NSC 652287) <1 mg/mL 115 mg/mL 4 mg/mL
A10522 Lenalidomide (CC-5013) <1 mg/mL 52 mg/mL <1 mg/mL
A10743 Pomalidomide (CC-4047) <1 mg/mL 55 mg/mL <1 mg/mL
A11163 AT-406 <1 mg/mL 112 mg/mL 112 mg/mL
A11002 YM155 89 mg/mL 55 mg/mL 6 mg/mL
A10935 Tipifarnib (Zarnestra) <1 mg/mL 83 mg/mL <1 mg/mL
A10657 Nutlin-3 <1 mg/mL 116 mg/mL 116 mg/mL

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