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$0.00 - Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
- Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
- Jose Mario Gonzalez-Meljem, .et al. Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma, Nat Commun, 2017, 8: 1819 PMID: 29180744
- Zhang C, .et al. S0rafenlb targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response, J Biol Chem, 2017, Sep 8;292(36):15105-15120 PMID: 28673964
- Eun Young Kim, .et al. ABT-737 Synergizes with Clsplatln Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer, Neoplasia, 2017, Apr; 19(4): 354-363 PMID: 28319809
- Masayoshi Toge, .et al. Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer., Int J Oncol., 2015, Apr;46(4):1844-8 PMID: 25647738
Biological Activity
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).
Targets
| Target | Value |
|---|---|
| Bcl-2 | EC50:30.3nM |
| Bcl-xL | EC50:78.7nM |
| Bcl-w | EC50:197.8nM |
| Bcl-B | EC50:1.82 uM |
| Bfl-1 | EC50>10 uM |
| Mcl-1 | EC50>10 uM |
| In vitro (25°C) | DMSO | 100 mg/mL (122.93 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.29 mL | 61.47 mL | 122.94 mL |
| 0.5 mM | 2.46 mL | 12.29 mL | 24.59 mL |
| 1 mM | 1.23 mL | 6.15 mL | 12.29 mL |
| 5 mM | 0.25 mL | 1.23 mL | 2.46 mL |
*The above data is based on the productmolecular weight 813.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10255 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 813.4 |
| Formula | C42H45ClN6O5S2 |
| Solubility | DMSO>163mg/mL Water<1mg/mL Ethanol<1mg/mL |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 852808-04-9 |
| SMILES | CN(C)CC[[email protected]](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-] |
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