France
You have no items in your shopping cart.
Publications citing Adooq Products
ABT-737 Citations (5)
- Chauhan D,et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1汕 Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 30485805
- Jose Mario Gonzalez-Meljem,et al. Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma, Nat Commun, 2017, 8: 1819 29180744
- Zhang C,et al. Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response, J Biol Chem, 2017, Sep 8;292(36):15105-15120 28673964
- Eun Young Kim,et al. ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer, Neoplasia, 2017, Apr; 19(4): 354-363 28319809
- Masayoshi Toge,et al. Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer., Int J Oncol., 2015, Apr;46(4):1844-8 25647738
Chemical Information
| Catalog Num | A10255 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 813.4 |
| Formula | C42H45ClN6O5S2 |
| Solubility | DMSO>163mg/mL Water<1mg/mL Ethanol<1mg/mL |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 852808-04-9 |
| Synonyms | N/A |
| SMILES code | CN(C)CC[[email protected]](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-] |
| Chemical Name | 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide |
Description |
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60). | ||||||||||||||
Targets |
|
||||||||||||||
| Solubility (25°C) * | In vitro | DMSO | 100 mg/mL (122.93 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.29 mL | 61.47 mL | 122.94mL |
| 0.5 mM | 2.46 mL | 12.29 mL | 24.59 mL |
| 1 mM | 1.23 mL | 6.15 mL | 12.29 mL |
| 5 mM | 0.25 mL | 1.23 mL | 2.46 mL |
*The above data is based on the productmolecular weight 813.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|
Cat. No. | Product Name | Solubility(mg/mL) | ||
|---|---|---|---|---|
| Water | DMSO | Ethanol | ||
| A10255 | ABT-737 | <1 mg/mL | 163 mg/mL | <1 mg/mL |
| A10022 | ABT-263 (Navitoclax) | <1 mg/mL | 195 mg/mL | <1 mg/mL |
| A10665 | Obatoclax mesylate (GX15-070) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10955 | TW-37 | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10984 | VX-765 | <1 mg/mL | 102 mg/mL | 102 mg/mL |
| A11090 | PAC-1 | <1 mg/mL | 78 mg/mL | 16 mg/mL |
| A10491 | JNJ 26854165 | <1 mg/mL | 66 mg/mL | 2 mg/mL |
| A11931 | RITA (NSC 652287) | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10522 | Lenalidomide (CC-5013) | <1 mg/mL | 52 mg/mL | <1 mg/mL |
| A10743 | Pomalidomide (CC-4047) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| A11163 | AT-406 | <1 mg/mL | 112 mg/mL | 112 mg/mL |
| A11002 | YM155 | 89 mg/mL | 55 mg/mL | 6 mg/mL |
| A10935 | Tipifarnib (Zarnestra) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10657 | Nutlin-3 | <1 mg/mL | 116 mg/mL | 116 mg/mL |
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
€42.75
ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins . ...
Special Price Starting at: €42.75
Special Price Starting at:
€76.00
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM. ...
Special Price Starting at: €76.00
Special Price Starting at:
€51.30
LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplast ...
Special Price Starting at: €51.30
Special Price Starting at:
€332.50
Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectivel ...
Special Price Starting at: €332.50
Special Price Starting at:
€128.25
ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens. ...
Special Price Starting at: €128.25
Special Price Starting at:
€95.00
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID
...
Special Price Starting at: €95.00
Special Price Starting at:
€34.20
Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively.
...
Special Price Starting at: €34.20
Special Price Starting at:
€114.00
A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki ??0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related protei ...
Special Price Starting at: €114.00
Special Price Starting at:
€137.75
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
...
Special Price Starting at: €137.75
Special Price Starting at:
€76.95
Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). ...
Special Price Starting at: €76.95
Special Price Starting at:
€57.00
A-1210477 is a potent and selective MCL-1 inhibitor. A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cel ...
Special Price Starting at: €57.00
Special Price Starting at:
€59.85
Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 a ...
Special Price Starting at: €59.85
Special Price Starting at:
€114.00
Muristerone A is a phytoecdysteroid analog of ecdysone which induces genes in mammalian cells and causes apoptosis in cells transfected with wild-type Bax. ...
Special Price Starting at: €114.00
Special Price Starting at:
€68.40
ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. ...
Special Price Starting at: €68.40
Special Price Starting at:
€85.50
UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.
...
Special Price Starting at: €85.50
Special Price Starting at:
€76.00
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1. ...
Special Price Starting at: €76.00
Special Price Starting at:
€114.00
A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML. ...
Special Price Starting at: €114.00
Special Price Starting at:
€102.60
ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2. ...
Special Price Starting at: €102.60
Special Price Starting at:
€38.00
ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor. ...
Special Price Starting at: €38.00
Special Price Starting at:
€85.50
BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL ...
Special Price Starting at: €85.50
Special Price Starting at:
€133.00
BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM. ...
Special Price Starting at: €133.00
Keywords:buy ABT-737 | ABT-737 Supplier | purchase ABT-737 | ABT-737 cost | ABT-737 manufacturer | order ABT-737 | ABT-737 distributor | buy 852808-04-9| 852808-04-9 Supplier | purchase 852808-04-9 | 852808-04-9 cost | 852808-04-9 manufacturer | order 852808-04-9 | 852808-04-9 distributor
We Using Safe Payments:
