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Obatoclax mesylate (GX15-070)

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Bcl-2 Inhibitor

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Catalog No. A10665

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Obatoclax mesylate 5mg A10665-5

Regular Price: €85.50

Special Price: €76.95

Obatoclax mesylate 10mg A10665-10

Regular Price: €152.00

Special Price: €136.80

Obatoclax mesylate 25mg A10665-25

Regular Price: €285.00

Special Price: €256.50

Obatoclax mesylate 50mg A10665-50

Regular Price: €494.00

Special Price: €444.60

Obatoclax mesylate 10mM * 1mL in DMSO A10665-10mM-D

Regular Price: €90.25

Special Price: €81.23

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).

Obatoclax mesylate (GX15-070)

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Publications citing Adooq Products
Obatoclax mesylate (GX15-070) Citations (2)
  • Chi-Hung R. Or, .et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells, Int J Mol Sci, 2016, Jan; 18(1): 44 PMID: 28035994
  • P Geserick, .et al. The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin, Cell Death Dis., 2014, 5(9): e1412 PMID: 25210795

Chemical Information

Catalog Num A10665
Actions Inhibitor
M. Wt 413.5
Formula C20H19N3O.CH4O3S
Solubility DMSO>83mg/mL Water<1mg/mL Ethanol<1mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 803712-79-0
Synonyms N/A
SMILES code CC1=CC(=C(N1)/C=C/2\C(=C/C(=C\3/C=C4C=CC=CC4=N3)/N2)OC)C.CS(=O)(=O)O
Chemical Name 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate

Biological Activity

Description
Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).
Targets
Bcl-2 (Cell-free assay)
0.22 μM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 83 mg/mL (200.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.18 mL 120.92 mL 241.84mL
0.5 mM 4.84 mL 24.18 mL 48.37 mL
1 mM 2.42 mL 12.09 mL 24.18 mL
5 mM 0.48 mL 2.42 mL 4.84 mL

*The above data is based on the productmolecular weight 413.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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