- Silva S, .et al. A diarylamine derived from anthranilic acid inhibits ZIKV replication, Sci Rep, 2019, Nov 27;9(1):17703 PMID: 31776405
- Chi-Hung R. Or, .et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells, Int J Mol Sci, 2016, Jan; 18(1): 44 PMID: 28035994
- P Geserick, .et al. The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin, Cell Death Dis., 2014, 5(9): e1412 PMID: 25210795
Biological Activity
Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).
Targets
Bcl-2 (Cell-free assay) | ||||
0.22 μM(Ki) |
In vitro (25°C) | DMSO | 81 mg/mL (195.89 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.18 mL | 120.92 mL | 241.84 mL |
0.5 mM | 4.84 mL | 24.18 mL | 48.37 mL |
1 mM | 2.42 mL | 12.09 mL | 24.18 mL |
5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
*The above data is based on the productmolecular weight 413.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10665 |
---|---|
Actions | Inhibitor |
CAS No. | 803712-79-0 |
Formula | C20H19N3O.CH4O3S |
M. Wt | 413.5 |
Purity | >98% |
SMILES | CC1=CC(=C(N1)/C=C/2\C(=C/C(=C\3/C=C4C=CC=CC4=N3)/N2)OC)C.CS(=O)(=O)O |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
ABT-737
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to
UMI-77
UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.
ABT-492 (Delafloxacin)
ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.
A-1331852
A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic targ…
ABT-199 (Venetoclax)
ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.
Linifanib (ABT-869)
Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial c…
BH3I-1
BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL
BM-1074
BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of
Keywords:buy Obatoclax mesylate (GX15-070) | Obatoclax mesylate (GX15-070) Supplier | purchase | cost | manufacturer | order | distributor | buy 803712-79-0| 803712-79-0 Supplier | purchase 803712-79-0 | 803712-79-0 cost | 803712-79-0 manufacturer | order 803712-79-0 | 803712-79-0 distributor