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Biological Activity
MIK665 (S-64315) is a special Mcl-1 inhibitor extracted from patent WO2016207225A1, compound Preparation 13, has an IC50 of 1.81 nM.
| In vitro | DMSO | 92 mg/mL (105.09 mM) | |
| Water | Insoluble | ||
| Ethanol | <1 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 11.42 mL | 57.12 mL | 114.23 mL |
| 0.5 mM | 2.28 mL | 11.42 mL | 22.85 mL |
| 1 mM | 1.14 mL | 5.71 mL | 11.42 mL |
| 5 mM | 0.23 mL | 1.14 mL | 2.28 mL |
*The above data is based on the productmolecular weight 875.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18362 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1799631-75-6 |
| Formula | C47H44ClFN6O6S |
| M. Wt | 875.41 |
| Purity | >98% |
| Synonyms | MIK665; MIK-665; MIK 665; S 64315; S-64315; S64315 |
| SMILES | OC([[email protected]@H](CC(C=CC=C1)=C1OCC2=CC=NC(C3=CC=CC=C3OC)=N2)OC4=C5[[email protected]]([[email protected]]6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6)=C(C8=CC=C(F)C=C8)SC5=NC=N4)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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