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$0.00 Biological Activity
Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
Targets
| Target | Value | |
|---|---|---|
| Bcl-w | IC50: 0.02μM | |
| Bcl-B | IC50: 0.66μM | |
| Mcl-1 | IC50: 0.79μM | |
| Bfl-1 | IC50: 1.06μM | |
| Bcl-2 | IC50: 1.21μM | |
| Bcl-xL | IC50: 1.47μM | |
| Caspase | EC50 | <1.64μM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.9 mL | 79.52 mL | 159.05 mL |
| 0.5 mM | 3.18 mL | 15.9 mL | 31.81 mL |
| 1 mM | 1.59 mL | 7.95 mL | 15.9 mL |
| 5 mM | 0.32 mL | 1.59 mL | 3.18 mL |
*The above data is based on the productmolecular weight 628.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11988 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 628.75 |
| Formula | C38H44O8 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 2752-65-0 |
| SMILES | CC(=CCC[[email protected]@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[[email protected]@H]5C[[email protected]@H]6[[email protected]@]4(O3)[[email protected]](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C |
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