Fig. 1 · Structure

Cat. No.: A11988
CAS No.: 2752-65-0
Formula: C₃₈H₄₄O₈
Mol. Weight: 628.75

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Gambogic acid

Name: Gambogic acid
Brand: Adooq Bioscience
SKU: A11988
Availability: InStock
Rating: 5 (1 reviews)

Cat. No. A11988 CAS 2752-65-0

Bcl-2 inhibitor

Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.

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Biological Activity

Target & Activity

Target	Activity	Value
Bcl-w	IC50	0.02μM
Bcl-B	IC50	0.66μM
Mcl-1	IC50	0.79μM
Bfl-1	IC50	1.06μM
Bcl-2	IC50	1.21μM
Bcl-xL	IC50	1.47μM
Caspase	EC50	<1.64μM

7 targets · Scroll to view more

Cellular Effect

Cell Line	Activity	Value	Description	Reference
A549	IC50	0.29 μM	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31546197]
A549	IC50	0.5 μg/mL	Cytotoxicity against human A549 cells by MTT assay	[PMID: 22595179]
A549	IC50	1.1 μM	Cytotoxicity against human A549 cells assessed as growth inhibition after 24 hrs by MTT assay	[PMID: 25958244]
A549	IC50	1.1 μM	Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 23167526]
A549	IC50	1.1 μM	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 22472167]
A549	IC50	1.2 μM	Antiproliferative activity against human A549 cells assessed as growth inhibition by MTT assay	[PMID: 27527413]
A549	IC50	1.47 μM	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
A549	IC50	3.4 μM	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 to 48 hrs by Presto Blue assay	[PMID: 27216998]
A549	IC50	3.65 μM	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 20605273]
A549	IC50	5.81 μM	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 18996626]
A549/CDDP	IC50	0.29 μM	Antiproliferative activity against human A549/CDDP cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31546197]
A549/TR	IC50	0.29 μM	Antiproliferative activity against human A549/TR cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31546197]
Bel-7402	IC50	0.75 μM	Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 22153338]
Bel-7402	IC50	2.08 μM	Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay	[PMID: 20605273]
Bel-7402	IC50	3.31 μM	Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay	[PMID: 18996626]
BEL-7404 tumor cell line	IC50	4.7 μM	Cytotoxicity against human Bel7404 cells after 72 hrs by MTT assay	[PMID: 22153338]
BGC-823	IC50	2.35 μM	Antiproliferative activity against human BGC823 cells after 24 hrs by MTT assay	[PMID: 21334116]
BGC-823	IC50	2.83 μM	Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay	[PMID: 20605273]
BGC-823	IC50	4.51 μM	Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay	[PMID: 18996626]
Breast carcinoma cell	IC50	0.42 μM	Cytotoxicity against patient derived inflammatory breast cancer cell spheroids assessed as increase in spheroid dissolution incubated for 24 hrs by propidium iodide/Acridine orange staining based dual-fluorescence viability assay	[PMID: 30831408]

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2752-65-0
Applications	Bcl-2 inhibitor
Formula	C₃₈H₄₄O₈
Molecular Weight	628.75
SMILES	CC(=CCC[C@@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[C@@H]5C[C@@H]6[C@@]4(O3)[C@](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	97 mg/mL (154.27 mM)
Water	Insoluble
Ethanol	97 mg/mL (154.27 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 3 mg/mL
Vehicle: 2% DMSO+40% PEG 300+2% Tween 80+ddH2O

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Publications

1 publication citing this product

Ella Martin, .et al. , ACS Pharmacol Transl Sci, 2025, May 12;8(9):2996-3006 PMID: 40969890