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Publications citing Adooq Products
Chemical Information
| Catalog Num | A11988 |
|---|---|
| Actions | No |
| M. Wt | 628.75 |
| Formula | C38H44O8 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 2752-65-0 |
| Synonyms | N/A |
| SMILES code | CC(=CCC[[email protected]@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[[email protected]@H]5C[[email protected]@H]6[[email protected]@]4(O3)[[email protected]](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C |
| Chemical Name | (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14a?S)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-?13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7?,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[?3,2-b]xanthen-1-yl]-2-butenoic acid |
Description |
Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively. | |||||||||||||||||
Targets |
|
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.9 mL | 79.52 mL | 159.05mL |
| 0.5 mM | 3.18 mL | 15.9 mL | 31.81 mL |
| 1 mM | 1.59 mL | 7.95 mL | 15.9 mL |
| 5 mM | 0.32 mL | 1.59 mL | 3.18 mL |
*The above data is based on the productmolecular weight 628.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|
Cat. No. | Product Name | Solubility(mg/mL) | ||
|---|---|---|---|---|
| Water | DMSO | Ethanol | ||
| A10255 | ABT-737 | <1 mg/mL | 163 mg/mL | <1 mg/mL |
| A10022 | ABT-263 (Navitoclax) | <1 mg/mL | 195 mg/mL | <1 mg/mL |
| A10665 | Obatoclax mesylate (GX15-070) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10955 | TW-37 | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10984 | VX-765 | <1 mg/mL | 102 mg/mL | 102 mg/mL |
| A11090 | PAC-1 | <1 mg/mL | 78 mg/mL | 16 mg/mL |
| A10491 | JNJ 26854165 | <1 mg/mL | 66 mg/mL | 2 mg/mL |
| A11931 | RITA (NSC 652287) | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10522 | Lenalidomide (CC-5013) | <1 mg/mL | 52 mg/mL | <1 mg/mL |
| A10743 | Pomalidomide (CC-4047) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| A11163 | AT-406 | <1 mg/mL | 112 mg/mL | 112 mg/mL |
| A11002 | YM155 | 89 mg/mL | 55 mg/mL | 6 mg/mL |
| A10935 | Tipifarnib (Zarnestra) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10657 | Nutlin-3 | <1 mg/mL | 116 mg/mL | 116 mg/mL |
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