Gambogic acid

Catalog No.: A11988

Bcl-2 inhibitor

Gambogic acid

Gambogic acid Chemical Structure

CAS NO. 2752-65-0

Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.

Availability: In stock

Package Price Qty
10 mg
$70.00
25 mg
$180.00
50 mg
$300.00
100 mg
$500.00
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Biological Activity

Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
Targets
Target Value
Bcl-wIC50: 0.02μM
Bcl-BIC50: 0.66μM
Mcl-1IC50: 0.79μM
Bfl-1IC50: 1.06μM
Bcl-2IC50: 1.21μM
Bcl-xLIC50: 1.47μM
CaspaseEC50<1.64μM
In vitro (25°C) DMSO 97 mg/mL (154.27 mM)
Water Insoluble
Ethanol 97 mg/mL (154.27 mM)
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.9 mL 79.52 mL 159.05 mL
0.5 mM 3.18 mL 15.9 mL 31.81 mL
1 mM 1.59 mL 7.95 mL 15.9 mL
5 mM 0.32 mL 1.59 mL 3.18 mL

*The above data is based on the productmolecular weight 628.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11988
Actions Inhibitor
CAS No. 2752-65-0
Formula C38H44O8
M. Wt 628.75
Purity >98%
SMILES CC(=CCC[[email protected]@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[[email protected]@H]5C[[email protected]@H]6[[email protected]@]4(O3)[[email protected]](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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