Gambogic acid

Catalog No.: A11988

Bcl-2 inhibitor

Gambogic acid Chemical Structure

CAS NO. 2752-65-0

Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $70.00

Special Price $56.00

25 mg

Regular Price: $180.00

Special Price $144.00

50 mg

Regular Price: $300.00

Special Price $240.00

100 mg

Regular Price: $500.00

Special Price $400.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
Targets
Target Value
Bcl-wIC50: 0.02μM
Bcl-BIC50: 0.66μM
Mcl-1IC50: 0.79μM
Bfl-1IC50: 1.06μM
Bcl-2IC50: 1.21μM
Bcl-xLIC50: 1.47μM
CaspaseEC50<1.64μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.9 mL 79.52 mL 159.05 mL
0.5 mM 3.18 mL 15.9 mL 31.81 mL
1 mM 1.59 mL 7.95 mL 15.9 mL
5 mM 0.32 mL 1.59 mL 3.18 mL

*The above data is based on the productmolecular weight 628.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11988
M. Wt 628.75
Formula C38H44O8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2752-65-0
SMILES CC(=CCC[[email protected]@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[[email protected]@H]5C[[email protected]@H]6[[email protected]@]4(O3)[[email protected]](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C

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