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ABT-263 (Navitoclax)

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Bcl-2 inhibitor

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Catalog No. A10022

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Product Name Catalog No. Price Qty
ABT-263 5mg A10022-5

Regular Price: €47.50

Special Price: €42.75

ABT-263 10mg A10022-10

Regular Price: €66.50

Special Price: €59.85

ABT-263 25mg A10022-25

Regular Price: €133.00

Special Price: €119.70

ABT-263 100mg A10022-100

Regular Price: €332.50

Special Price: €299.25

ABT-263 (Navitoclax) 10mM * 1mL in DMSO A10022-10mM-D

Regular Price: €148.20

Special Price: €133.38

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins .

ABT-263 (Navitoclax)

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Publications citing Adooq Products
ABT-263 (Navitoclax) Citations (8)
  • Shinya Ishida,et al. Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2, Oncotarget, 2018, Jun 1; 9(42): 26834-26851 29928488
  • Rhys Anderson,et al. Length-independent telomere damage drives cardiomyocyte senescence, bioRxiv, 2018, 2018
  • Ryuta Mikawa,et al. Elimination of p19ARF坼expressing cells protects against pulmonary emphysema in mice, Aging Cell, 2018, Oct; 17(5): e12827 30058137
  • Joo Sang Lee,et al. Harnessing synthetic lethality to predict the response to cancer treatment, Nat Commun, 2018, 9: 2546 29959327
  • Toshiyuki Sumi,et al. Survivin knockdown induces senescence in TTF-1-expressing, KRAS-mutant lung adenocarcinomas, Int J Oncol, 2018, Jul; 53(1): 33-46 29658609
  • Wei TW,et al. Aurora A and NF-百B Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA, Cancer Res, 2017, Jan 15;77(2):494-508 28069801
  • Yusuke Takagi,et al. SPIB is a novel prognostic factor in diffuse large B坼cell lymphoma that mediates apoptosis via the PI3K坼AKT pathway, Cancer Sci, 2016, Sep; 107(9): 1270-1280 27348272
  • Matsumoto M,et al. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells, Biochem Biophys Res Commun, 2016, Apr 29;473(2):490-6 26996126

Chemical Information

Catalog Num A10022
Actions Inhibitor
M. Wt 974.6
Formula C47H55ClF3N5O6S3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 923564-51-6
Synonyms ABT263
SMILES code CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[[email protected]](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Chemical Name (R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide

Biological Activity

Description
ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins .
Targets
Bcl-xL (Cell-free assay) Bcl-2 (Cell-free assay) Bcl-w (Cell-free assay) A1 (Cell-free assay) Mcl-1 (Cell-free assay)
<=0.5 nM(Ki)<=1 nM(Ki)<=1 nM(Ki)354 nM(Ki)550 nM(Ki)
Cell data
Cell LinesAssay TypeActivity (IC50 μM)Source
MHH-NB-11Growth Inhibition Assay2.511582418Sanger
TYK-nuGrowth Inhibition Assay30.03444831Sanger
GMS-10Growth Inhibition Assay26.86380926Sanger
HNGrowth Inhibition Assay15.59421481Sanger
KYSE-140Growth Inhibition Assay131.1040129Sanger
J82Growth Inhibition Assay8.900380245Sanger
SW900Growth Inhibition Assay21.01492711Sanger
RT-112Growth Inhibition Assay20.61217664Sanger
NCI-H747Growth Inhibition Assay238.4429313Sanger
KYSE-180Growth Inhibition Assay61.94438708Sanger
SW1783Growth Inhibition Assay7.431747305Sanger
IST-MES1Growth Inhibition Assay108.9812664Sanger
GI-ME-NGrowth Inhibition Assay229.4467554Sanger
T47DGrowth Inhibition Assay115.0095306Sanger
NCI-H2228Growth Inhibition Assay14.60765929Sanger
NCI-H226Growth Inhibition Assay162.2398831Sanger
SNU1Growth Inhibition Assay1.365546889Sanger
EW-11Growth Inhibition Assay1.956570117Sanger
EW-13Growth Inhibition Assay0.583409464Sanger
KARPAS-45Growth Inhibition Assay0.078148298Sanger
NCI-H1299Growth Inhibition Assay119.1909704Sanger
ETK-1Growth Inhibition Assay39.02197699Sanger
KYSE-520 cell lineGrowth Inhibition Assay25.64400959Sanger
LU-139Growth Inhibition Assay0.204980997Sanger
COLO-829Growth Inhibition Assay85.88962142Sanger
CAL-39Growth Inhibition Assay72.1986249Sanger
A704Growth Inhibition Assay0.426701318Sanger
C2BBe1Growth Inhibition Assay4.740084678Sanger
BALL-1Growth Inhibition Assay47.61676952Sanger
Ca-SkiGrowth Inhibition Assay7.993830047Sanger
CAL-62Growth Inhibition Assay115.0576147Sanger
ChaGo-K-1Growth Inhibition Assay58.06697002Sanger
CW-2Growth Inhibition Assay56.69698303Sanger
639-VGrowth Inhibition Assay52.1621429Sanger
BB65-RCCGrowth Inhibition Assay4.043994738Sanger
8-MG-BAGrowth Inhibition Assay152.2964576Sanger
CHL-1Growth Inhibition Assay121.5359374Sanger
CAS-1Growth Inhibition Assay132.4120962Sanger
G-401Growth Inhibition Assay260.4922213Sanger
JVM-3Growth Inhibition Assay4.182223321Sanger
MN-60Growth Inhibition Assay11.53903921Sanger
NCI-H82Growth Inhibition Assay3.959362391Sanger
NCI-H1048Growth Inhibition Assay0.509532317Sanger
ES7Growth Inhibition Assay1.279505916Sanger
SW837Growth Inhibition Assay15.78468238Sanger
SW872Growth Inhibition Assay15.30860364Sanger
BT-474Growth Inhibition Assay136.2733779Sanger
NCI-H650Growth Inhibition Assay183.1777513Sanger
OE19Growth Inhibition Assay5.686244428Sanger
EM-2Growth Inhibition Assay0.19917947Sanger
D-392MGGrowth Inhibition Assay255.4235123Sanger
BPH-1Growth Inhibition Assay18.16845775Sanger
D-423MGGrowth Inhibition Assay226.0018082Sanger
COLO-668Growth Inhibition Assay6.843867529Sanger
HuP-T4Growth Inhibition Assay17.24944553Sanger
MDA-MB-415Growth Inhibition Assay1.388499961Sanger
KNS-62Growth Inhibition Assay16.97768781Sanger
SW1088Growth Inhibition Assay103.6042135Sanger
NCI-H1650Growth Inhibition Assay2.722149975Sanger
NCI-H1651Growth Inhibition Assay86.97032774Sanger
NCI-H446Growth Inhibition Assay6.62925215Sanger
NCI-H460Growth Inhibition Assay182.5881372Sanger
TE-9Growth Inhibition Assay47.95811376Sanger
GAMGGrowth Inhibition Assay10.51615872Sanger
IA-LMGrowth Inhibition Assay5.398709805Sanger
MZ7-melGrowth Inhibition Assay148.9475157Sanger
KOSC-2Growth Inhibition Assay72.12494772Sanger
OAW-42Growth Inhibition Assay0.961459343Sanger
OC-314Growth Inhibition Assay49.6834063Sanger
HDLM-2Growth Inhibition Assay33.69313138Sanger
TE-10Growth Inhibition Assay196.765566Sanger
RDGrowth Inhibition Assay0.758985201Sanger
NCI-H292Growth Inhibition Assay25.35358145Sanger
RCC10RGBGrowth Inhibition Assay8.995612874Sanger
MDA-MB-231Growth Inhibition Assay121.4292757Sanger
HuCCT1Growth Inhibition Assay115.261908Sanger
MCF7Growth Inhibition Assay45.50512696Sanger
T98GGrowth Inhibition Assay18.51566258Sanger
NCI-H1581Growth Inhibition Assay2.796811449Sanger
EW-18Growth Inhibition Assay0.068406187Sanger
LB1047-RCCGrowth Inhibition Assay6.476252337Sanger
SNU-387Growth Inhibition Assay66.49149202Sanger
SW1710Growth Inhibition Assay30.12604259Sanger
J-RT3-T3-5Growth Inhibition Assay0.608082935Sanger
SW1990Growth Inhibition Assay4.059078592Sanger
No DataGrowth Inhibition Assay0.5Scientific Literature
NCI-H187Growth Inhibition Assay38.4Scientific Literature
EOL1Growth Inhibition Assay0.006693449Sanger
NOS-1Growth Inhibition Assay3.798343308Sanger
HCE-4Growth Inhibition Assay110.5017104Sanger
RH-1Growth Inhibition Assay97.18749005Sanger
OVCAR-4Growth Inhibition Assay16.8862385Sanger
JVM-2Growth Inhibition Assay240.5175356Sanger
DU-4475Growth Inhibition Assay0.65427011Sanger
BV-173Growth Inhibition Assay0.023136912Sanger
NCI-H2030Growth Inhibition Assay47.23740228Sanger
LS-1034Growth Inhibition Assay107.2310658Sanger
TGBC24TKBGrowth Inhibition Assay0.457775678Sanger
U-118-MGGrowth Inhibition Assay2.964910955Sanger
OVCAR-8Growth Inhibition Assay27.06382594Sanger
MG-63Growth Inhibition Assay211.0029259Sanger
K-562Growth Inhibition Assay50.68059015Sanger
MKN28Growth Inhibition Assay33.38093738Sanger
KYSE-410Growth Inhibition Assay16.59101029Sanger
LU-134-AGrowth Inhibition Assay0.186705457Sanger
ESS-1Growth Inhibition Assay5.255972242Sanger
HAL-01Growth Inhibition Assay0.72548564Sanger
COLO-678Growth Inhibition Assay65.2431461Sanger
RPMI-8866Growth Inhibition Assay17.17318233Sanger
GI-1Growth Inhibition Assay5.279255057Sanger
T-24Growth Inhibition Assay17.53468641Sanger
UMC-11Growth Inhibition Assay4.889636669Sanger
NCI-H1623Growth Inhibition Assay4.702282363Sanger
HCC70Growth Inhibition Assay32.13867071Sanger
MOLT-13Growth Inhibition Assay0.466129867Sanger
HCC2218Growth Inhibition Assay38.65186394Sanger
KG-1Growth Inhibition Assay0.044862725Sanger
KGNGrowth Inhibition Assay183.8231217Sanger
LXF-289 cell lineGrowth Inhibition Assay5.037188051Sanger
MOLT-4Growth Inhibition Assay0.151693537Sanger
MC-IXCGrowth Inhibition Assay12.75183267Sanger
SF-268Growth Inhibition Assay126.1987443Sanger
ME-180Growth Inhibition Assay12.70543685Sanger
SW1116Growth Inhibition Assay37.59917091Sanger
SW1573Growth Inhibition Assay52.63156317Sanger
MeWoGrowth Inhibition Assay20.12876728Sanger
ACNGrowth Inhibition Assay40.49105154Sanger
C3AGrowth Inhibition Assay226.9046761Sanger
DMS-273Growth Inhibition Assay82.20433188Sanger
CAL-12TGrowth Inhibition Assay39.52806793Sanger
Calu-3Growth Inhibition Assay1.70696681Sanger
CHP-212Growth Inhibition Assay3.925485351Sanger
NCI-H23Growth Inhibition Assay21.12772164Sanger
DK-MGGrowth Inhibition Assay77.50287249Sanger
A388Growth Inhibition Assay1.687244964Sanger
BHYGrowth Inhibition Assay18.86897427Sanger
BeckerGrowth Inhibition Assay55.52931059Sanger
SW780Growth Inhibition Assay6.701845927Sanger
MHH-ES-1Growth Inhibition Assay8.518335859Sanger
786-0Growth Inhibition Assay121.43304Sanger
BCPAPGrowth Inhibition Assay4.634809046Sanger
BFTC-909Growth Inhibition Assay103.8793365Sanger
CCRF-CEMGrowth Inhibition Assay0.33528881Sanger
MFE-280Growth Inhibition Assay2.028482548Sanger
OCI-AML2Growth Inhibition Assay3.312721311Sanger
NCI-H2452Growth Inhibition Assay49.11522165Sanger
HT-1197Growth Inhibition Assay60.31042655Sanger
PA-1Growth Inhibition Assay0.956418213Sanger
PANC-03-27Growth Inhibition Assay22.5169194Sanger
PANC-08-13Growth Inhibition Assay3.634723347Sanger
SCC-25Growth Inhibition Assay11.75555624Sanger
L-428Growth Inhibition Assay1.012497449Sanger
UMUC3Growth Inhibition Assay75.54949467Sanger
S-117Growth Inhibition Assay142.7695797Sanger
NCI-H1155Growth Inhibition Assay5.549550869Sanger
HT-1080Growth Inhibition Assay9.777394133Sanger
NCI-H2347Growth Inhibition Assay12.76142565Sanger
NCI-H1963Growth Inhibition Assay26.6Scientific Literature
COLO-680NGrowth Inhibition Assay25.63290814Sanger
KP-N-YSGrowth Inhibition Assay1.162358348Sanger
NCI-H1792Growth Inhibition Assay17.79798057Sanger
KNS-81-FDGrowth Inhibition Assay0.440174077Sanger
MEG-01Growth Inhibition Assay0.583203557Sanger
SJSA-1Growth Inhibition Assay41.15959207Sanger
SKG-IIIaGrowth Inhibition Assay7.818916578Sanger
RPMI-2650Growth Inhibition Assay5.361603013Sanger
ATN-1Growth Inhibition Assay0.047333499Sanger
Calu-6Growth Inhibition Assay4.278810284Sanger
647-VGrowth Inhibition Assay71.9701896Sanger
CHP-134Growth Inhibition Assay0.16305691Sanger
DOKGrowth Inhibition Assay56.23250666Sanger
HHGrowth Inhibition Assay3.83867786Sanger
GR-STGrowth Inhibition Assay117.7714639Sanger
NCI-H1838Growth Inhibition Assay60.2159339Sanger
LN-405Growth Inhibition Assay158.3525696Sanger
ES5Growth Inhibition Assay4.139847701Sanger
EFO-21Growth Inhibition Assay77.13483544Sanger
DU-145Growth Inhibition Assay0.899231293Sanger
AN3-CAGrowth Inhibition Assay3.442383124Sanger
D283 MedGrowth Inhibition Assay0.176862975Sanger
MDA-MB-361Growth Inhibition Assay71.82344825Sanger
NUGC-3Growth Inhibition Assay7.396937033Sanger
LB996-RCCGrowth Inhibition Assay9.198900812Sanger
VA-ES-BJGrowth Inhibition Assay12.87849673Sanger
HCC1937Growth Inhibition Assay6.992512963Sanger
HT-29Growth Inhibition Assay166.276988Sanger
EW-22Growth Inhibition Assay0.466705893Sanger
KE-37Growth Inhibition Assay0.113696234Sanger
NCI-H1755Growth Inhibition Assay149.5793468Sanger
NCI-H522Growth Inhibition Assay15.3305566Sanger
IST-MEL1Growth Inhibition Assay21.3691651Sanger
NYGrowth Inhibition Assay57.95216912Sanger
IGR-1Growth Inhibition Assay2.62034503Sanger
LS-513Growth Inhibition Assay143.5215216Sanger
NCI-H2122Growth Inhibition Assay26.99978762Sanger
SK-PN-DWGrowth Inhibition Assay21.16487568Sanger
KALS-1Growth Inhibition Assay48.12890826Sanger
SiHaGrowth Inhibition Assay97.99740512Sanger
NCI-H2126Growth Inhibition Assay7.736249427Sanger
NCI-H1092Growth Inhibition Assay0.10275251Sanger
L-363Growth Inhibition Assay13.40330073Sanger
SNU-449Growth Inhibition Assay61.57500345Sanger
HCC38Growth Inhibition Assay0.801903502Sanger
LB2518-MELGrowth Inhibition Assay16.83888845Sanger
KM12Growth Inhibition Assay36.75473276Sanger
SNU-C2BGrowth Inhibition Assay43.68780494Sanger
YKG-1Growth Inhibition Assay76.14222705Sanger
AM-38Growth Inhibition Assay13.25663259Sanger
CAMA-1Growth Inhibition Assay20.98030205Sanger
AGSGrowth Inhibition Assay10.37395149Sanger
BHT-101Growth Inhibition Assay10.71769378Sanger
CGTH-W-1Growth Inhibition Assay17.52187324Sanger
C32Growth Inhibition Assay1.19088056Sanger
COLO-800Growth Inhibition Assay39.38677106Sanger
no-11Growth Inhibition Assay4.355541751Sanger
D-502MGGrowth Inhibition Assay73.00821726Sanger
D-566MGGrowth Inhibition Assay41.20860114Sanger
ES3Growth Inhibition Assay4.354409457Sanger
EFM-19Growth Inhibition Assay3.483390148Sanger
EKVXGrowth Inhibition Assay20.6059733Sanger
DELGrowth Inhibition Assay1.746923079Sanger
A673Growth Inhibition Assay84.40865975Sanger
SHP-77Growth Inhibition Assay77.74583652Sanger
UACC-893Growth Inhibition Assay27.98783636Sanger
NB13Growth Inhibition Assay0.082027313Sanger
SK-MEL-28Growth Inhibition Assay9.618929693Sanger
LS-123Growth Inhibition Assay99.61502434Sanger
KU812 cell lineGrowth Inhibition Assay19.95730018Sanger
NCI-H727Growth Inhibition Assay20.27036566Sanger
MIA PaCa-2Growth Inhibition Assay122.9329396Sanger
SW948Growth Inhibition Assay47.46402236Sanger
NCI-H69Growth Inhibition Assay12.42342744Sanger
NB69Growth Inhibition Assay1.462707251Sanger
ES8Growth Inhibition Assay2.254713694Sanger
H4Growth Inhibition Assay221.9233385Sanger
H9Growth Inhibition Assay3.671440163Sanger
RPMI-8226Growth Inhibition Assay0.456518981Sanger
SK-MEL-1Growth Inhibition Assay38.33893655Sanger
SW48Growth Inhibition Assay10.51889328Sanger
NB5Growth Inhibition Assay13.37518334Sanger
FDC-P1Growth Inhibition Assay0.06Scientific Literature
NCI-H1563Growth Inhibition Assay14.60393481Sanger
SNU-423Growth Inhibition Assay1.781571785Sanger
NKM-1Growth Inhibition Assay0.016985555Sanger
NOMO-1Growth Inhibition Assay6.78111132Sanger
HuO9Growth Inhibition Assay0.267145453Sanger
MV-4-11Growth Inhibition Assay0.01585648Sanger
NCI-H2170Growth Inhibition Assay1.062297484Sanger
NCI-H1573Growth Inhibition Assay171.6787504Sanger
SBC-1Growth Inhibition Assay1.190534064Sanger
NCI-H810Growth Inhibition Assay60.65596611Sanger
HSC-3Growth Inhibition Assay1.963651991Sanger
SCC-9Growth Inhibition Assay15.81138104Sanger
MKN7Growth Inhibition Assay15.97316298Sanger
KYSE-450Growth Inhibition Assay82.00399782Sanger
EW-16Growth Inhibition Assay0.813279858Sanger
HCC1954Growth Inhibition Assay81.0700017Sanger
LAMA-84Growth Inhibition Assay0.592073202Sanger
NBsusSRGrowth Inhibition Assay3.349379149Sanger
SK-MES-1Growth Inhibition Assay176.4423157Sanger
RVH-421Growth Inhibition Assay3.568770005Sanger
RXF393Growth Inhibition Assay68.64010604Sanger
U-2-OSGrowth Inhibition Assay5.890129595Sanger
KYSE-270Growth Inhibition Assay74.46282444Sanger
SW 954Growth Inhibition Assay4.296595651Sanger
SW982Growth Inhibition Assay145.2470376Sanger
HTC-C3Growth Inhibition Assay22.55545627Sanger
M14Growth Inhibition Assay110.8608709Sanger
NB6Growth Inhibition Assay4.8620395Sanger
NCI-H2052Growth Inhibition Assay1.722013077Sanger
NCI-H2087Growth Inhibition Assay31.6352182Sanger
NCI-H209Growth Inhibition Assay0.087038041Sanger
NCI-H720Growth Inhibition Assay0.040110465Sanger
RS4-11Growth Inhibition Assay0.025873992Sanger
LS-411NGrowth Inhibition Assay184.5698532Sanger
OS-RC-2Growth Inhibition Assay5.52603743Sanger
FTC-133Growth Inhibition Assay4.539500573Sanger
Huh-7Growth Inhibition Assay1.672932375Sanger
G-402Growth Inhibition Assay5.518654055Sanger
HCT-116Growth Inhibition Assay161.9136227Sanger
LB2241-RCCGrowth Inhibition Assay9.191369997Sanger
NTERA-2-cl-D1Growth Inhibition Assay0.500187625Sanger
LB771-HNCGrowth Inhibition Assay109.2516569Sanger
MZ1-PCGrowth Inhibition Assay107.3875228Sanger
MZ2-MELGrowth Inhibition Assay141.5245217Sanger
SNU-5Growth Inhibition Assay56.48488047Sanger
GAKGrowth Inhibition Assay288.1807824Sanger
TE-8Growth Inhibition Assay23.25648458Sanger
Mo-TGrowth Inhibition Assay4.04312133Sanger
KP-4Growth Inhibition Assay5.463343691Sanger
LC-2-adGrowth Inhibition Assay4.295684869Sanger
LCLC-103H cell lineGrowth Inhibition Assay22.15820817Sanger
MLMAGrowth Inhibition Assay1.966774714Sanger
MMAC-SFGrowth Inhibition Assay9.687496177Sanger
RH-18Growth Inhibition Assay0.060478279Sanger
HCC1569Growth Inhibition Assay0.251056065Sanger
SK-UT-1Growth Inhibition Assay9.049450159Sanger
Lu-65Growth Inhibition Assay93.07410465Sanger
HCC1419Growth Inhibition Assay4.900631136Sanger
OAW-28Growth Inhibition Assay0.78370469Sanger
LU-99AGrowth Inhibition Assay146.6686557Sanger
TGBC11TKBGrowth Inhibition Assay2.576814639Sanger
JEG-3Growth Inhibition Assay88.53898823Sanger
KY821Growth Inhibition Assay0.029747595Sanger
EGI-1Growth Inhibition Assay42.4280203Sanger
ECC10Growth Inhibition Assay0.037924611Sanger
CAKI-1Growth Inhibition Assay119.3213173Sanger
CAL-54Growth Inhibition Assay31.72411128Sanger
BB49-HNCGrowth Inhibition Assay70.80318602Sanger
CAL-85-1Growth Inhibition Assay66.98729671Sanger
CAPAN-1Growth Inhibition Assay7.773565971Sanger
CTV-1Growth Inhibition Assay9.565319449Sanger
ACHNGrowth Inhibition Assay11.4210712Sanger
CWR22RGrowth Inhibition Assay149.9176285Sanger
C8166Growth Inhibition Assay28.69382664Sanger
CTB-1Growth Inhibition Assay21.47548388Sanger
A101DGrowth Inhibition Assay69.07749567Sanger
BE-13Growth Inhibition Assay0.364586297Sanger
D-263MGGrowth Inhibition Assay119.5289976Sanger
D-336MGGrowth Inhibition Assay116.0415133Sanger
A2058Growth Inhibition Assay12.8680565Sanger
A253Growth Inhibition Assay124.6739588Sanger
A2780Growth Inhibition Assay51.02909703Sanger
BFTC-905Growth Inhibition Assay54.06672868Sanger
A172Growth Inhibition Assay178.9934119Sanger
SW626Growth Inhibition Assay3.245430477Sanger
HL-60Growth Inhibition Assay0.029084177Sanger
KS-1Growth Inhibition Assay17.67296375Sanger
SK-MEL-30Growth Inhibition Assay14.06452965Sanger
TGWGrowth Inhibition Assay0.046325718Sanger
Aspc-1Growth Inhibition Assay19.86572729Sanger
NCI-H1355Growth Inhibition Assay33.20405477Sanger
NCI-H1395Growth Inhibition Assay100.2298451Sanger
No DataGrowth Inhibition Assay4.3Scientific Literature
DJM-1Growth Inhibition Assay27.14535649Sanger
CAL-120Growth Inhibition Assay1.164289465Sanger
BENGrowth Inhibition Assay0.239677982Sanger
D-247MGGrowth Inhibition Assay1.51121959Sanger
NCI-H2342Growth Inhibition Assay1.402694458Sanger
DOHH-2Growth Inhibition Assay0.410232175Sanger
YH-13Growth Inhibition Assay8.610083359Sanger
QIMR-WILGrowth Inhibition Assay0.042865027Sanger
Panc1005Growth Inhibition Assay34.10141913Sanger
RCM-1Growth Inhibition Assay2.003993621Sanger
TE-1Growth Inhibition Assay136.3801218Sanger
COLO-684Growth Inhibition Assay8.018184302Sanger
DBGrowth Inhibition Assay0.57080422Sanger
COLO-320-HSRGrowth Inhibition Assay7.227382952Sanger
KM-H2Growth Inhibition Assay64.33198877Sanger
TE-12Growth Inhibition Assay8.59931028Sanger
COLO-792Growth Inhibition Assay1.200708741Sanger
A549Growth Inhibition Assay130.4844418Sanger
BXPC-3Growth Inhibition Assay81.1668571Sanger
C-33-AGrowth Inhibition Assay85.31420751Sanger
VMRC-RCZGrowth Inhibition Assay11.32008974Sanger
WM-115Growth Inhibition Assay0.277379964Sanger
NEC8Growth Inhibition Assay6.766297234Sanger
NB7Growth Inhibition Assay198.3553264Sanger
KP-N-YNGrowth Inhibition Assay0.235727925Sanger
RO82-W-1Growth Inhibition Assay64.45104865Sanger
MEL-HOGrowth Inhibition Assay7.770542642Sanger
GCIYGrowth Inhibition Assay3.204906767Sanger
HGC-27Growth Inhibition Assay87.99948833Sanger
NCI-H520Growth Inhibition Assay192.3458397Sanger
HCE-TGrowth Inhibition Assay7.877834055Sanger
HuP-T3Growth Inhibition Assay74.61100377Sanger
TE-5Growth Inhibition Assay3.707085543Sanger
MDA-MB-453Growth Inhibition Assay186.2289815Sanger
NCI-H1666Growth Inhibition Assay82.202359Sanger
no-10Growth Inhibition Assay107.4347837Sanger
NCI-H441Growth Inhibition Assay20.00099455Sanger
SW1463Growth Inhibition Assay44.99705306Sanger
PC-3Growth Inhibition Assay157.4078173Sanger
HT55Growth Inhibition Assay108.6020192Sanger
HT-3Growth Inhibition Assay17.59136224Sanger
P12-IchikawaGrowth Inhibition Assay0.077783341Sanger
SK-N-DZGrowth Inhibition Assay16.61157929Sanger
P30-OHKGrowth Inhibition Assay1.046884908Sanger
SASGrowth Inhibition Assay34.45651175Sanger
SW962Growth Inhibition Assay65.19670951Sanger
ML-2Growth Inhibition Assay0.019825486Sanger
HTGrowth Inhibition Assay188.6599145Sanger
KARPAS-299Growth Inhibition Assay3.673614299Sanger
5637Growth Inhibition Assay3.611029819Sanger
COR-L88Growth Inhibition Assay0.365401328Sanger
NCI-H28Growth Inhibition Assay226.5781685Sanger
IST-SL1Growth Inhibition Assay0.353434889Sanger
NB12Growth Inhibition Assay0.231150099Sanger
OMC-1Growth Inhibition Assay1.86016278Sanger
SK-HEP-1Growth Inhibition Assay135.2282376Sanger
A-427Growth Inhibition Assay0.930222011Sanger
HMV-2 cell lineGrowth Inhibition Assay31.35917852Sanger
KU-19-19Growth Inhibition Assay91.75142333Sanger
MFM-223Growth Inhibition Assay15.18129382Sanger
A4-FukGrowth Inhibition Assay188.4153812Sanger
RPMI-7951Growth Inhibition Assay4.224128638Sanger
SK-MEL-3Growth Inhibition Assay6.429154265Sanger
SW684Growth Inhibition Assay157.170468Sanger
SW756Growth Inhibition Assay7.78332792Sanger
GP5dGrowth Inhibition Assay4.783875538Sanger
JARGrowth Inhibition Assay161.9714362Sanger
KURAMOCHIGrowth Inhibition Assay67.24387929Sanger
U-266Growth Inhibition Assay195.8703577Sanger
No DataGrowth Inhibition Assay30Scientific Literature
No DataGrowth Inhibition Assay0.0033Scientific Literature
BT-20Growth Inhibition Assay8.260523804Sanger
NCI-H1993Growth Inhibition Assay119.2735984Sanger
TK-10Growth Inhibition Assay16.94729103Sanger
ES6Growth Inhibition Assay94.7956953Sanger
MHH-PREB-1Growth Inhibition Assay66.279457Sanger
NB17Growth Inhibition Assay0.071237066Sanger
H-EMC-SSGrowth Inhibition Assay4.318309473Sanger
LU-135Growth Inhibition Assay0.18551881Sanger
MKN45Growth Inhibition Assay140.2719446Sanger
SK-N-FIGrowth Inhibition Assay48.0357728Sanger
SK-NEP-1Growth Inhibition Assay0.072129151Sanger
HPAF-IIGrowth Inhibition Assay0.926281588Sanger
YAPCGrowth Inhibition Assay83.23259184Sanger
NB10Growth Inhibition Assay26.31165508Sanger
NCI-H1770Growth Inhibition Assay6.208740144Sanger
SK-MEL-24Growth Inhibition Assay20.14769722Sanger
CAL-27Growth Inhibition Assay19.04872176Sanger
NCI-N87Growth Inhibition Assay7.19292569Sanger
SNB75Growth Inhibition Assay105.5159367Sanger
HCC1806Growth Inhibition Assay7.260436856Sanger
COLO-679Growth Inhibition Assay195.2008444Sanger
SBC-5Growth Inhibition Assay244.638106Sanger
DBTRG-05MGGrowth Inhibition Assay120.0390372Sanger
NCI-H1793Growth Inhibition Assay134.2583596Sanger
NCI-H526Growth Inhibition Assay11.50427839Sanger
A-375Growth Inhibition Assay30.32428874Sanger
ONS-76Growth Inhibition Assay107.0680914Sanger
U-251Growth Inhibition Assay135.6106619Sanger
SAOS-2Growth Inhibition Assay42.83690511Sanger
EW-1Growth Inhibition Assay15.54618079Sanger
HCC1187Growth Inhibition Assay74.96152636Sanger
SK-OV-3Growth Inhibition Assay218.5673052Sanger
KYSE-70 cell lineGrowth Inhibition Assay8.077286606Sanger
SK-LU-1Growth Inhibition Assay4.660888056Sanger
SK-N-ASGrowth Inhibition Assay74.46006936Sanger
KNS-42Growth Inhibition Assay12.99840945Sanger
NCI-H630Growth Inhibition Assay5.994042145Sanger
Capan-2Growth Inhibition Assay18.90780879Sanger
NCI-H596Growth Inhibition Assay3.049973799Sanger
Detroit 562Growth Inhibition Assay180.9596358Sanger
DaoyGrowth Inhibition Assay96.30661423Sanger
EFO-27Growth Inhibition Assay76.68821147Sanger
DMS-114Growth Inhibition Assay66.9560879Sanger
EPLC-272HGrowth Inhibition Assay9.37656977Sanger
CAL-33Growth Inhibition Assay96.98564715Sanger
COR-L105Growth Inhibition Assay16.65276053Sanger
AU565Growth Inhibition Assay101.8597635Sanger
CAL-51Growth Inhibition Assay167.4823546Sanger
CAL-72Growth Inhibition Assay102.9183546Sanger
ALL-POGrowth Inhibition Assay0.219875896Sanger
COR-L23Growth Inhibition Assay1.798739245Sanger
Ca9-22Growth Inhibition Assay12.94508268Sanger
OCUB-MGrowth Inhibition Assay57.13923451Sanger
TGBC1TKBGrowth Inhibition Assay1.1415249Sanger
LCLC-97TM1Growth Inhibition Assay223.5551188Sanger
LK-2Growth Inhibition Assay4.112931358Sanger
NCI-H1648Growth Inhibition Assay1.714176859Sanger
SF539Growth Inhibition Assay173.9119262Sanger
MDA-MB-157Growth Inhibition Assay4.887603004Sanger
Hs-578-TGrowth Inhibition Assay189.9627499Sanger
RMG-IGrowth Inhibition Assay0.494636564Sanger
MDA-MB-175-VIIGrowth Inhibition Assay18.92091644Sanger
MSTO-211HGrowth Inhibition Assay181.6442311Sanger
FaDuGrowth Inhibition Assay182.6831077Sanger
RKOGrowth Inhibition Assay101.0576352Sanger
TCC-SUPGrowth Inhibition Assay73.74535425Sanger
LAN-6Growth Inhibition Assay4.451886772Sanger
NH-12Growth Inhibition Assay0.107442334Sanger
MC116Growth Inhibition Assay6.938967582Sanger
NCI-H1437Growth Inhibition Assay128.7915235Sanger
SCHGrowth Inhibition Assay72.74746063Sanger
M059JGrowth Inhibition Assay12.77272451Sanger
MOLT-16Growth Inhibition Assay0.652644962Sanger
SCC-15Growth Inhibition Assay5.93662031Sanger
NCI-H2405Growth Inhibition Assay2.827816898Sanger
SCC-4Growth Inhibition Assay1.598869793Sanger
697Growth Inhibition Assay0.108389398Sanger
CFPAC-1Growth Inhibition Assay33.23325396Sanger
A204Growth Inhibition Assay42.63877284Sanger
FDC-P1Growth Inhibition Assay0.015Scientific Literature
NCI-H1417Growth Inhibition Assay54.2Scientific Literature
SK-MEL-2Growth Inhibition Assay11.76365861Sanger
LNCaP-Clone-FGCGrowth Inhibition Assay105.5601571Sanger
OE33Growth Inhibition Assay66.67406188Sanger
HO-1-N-1Growth Inhibition Assay48.74448194Sanger
TI-73Growth Inhibition Assay8.258508482Sanger
SW620Growth Inhibition Assay4.570570349Sanger
HLEGrowth Inhibition Assay44.08563533Sanger
GOTOGrowth Inhibition Assay2.65377459Sanger
OVCAR-3Growth Inhibition Assay7.330377388Sanger
GT3TKBGrowth Inhibition Assay75.74458828Sanger
NMC-G1Growth Inhibition Assay0.811206203Sanger
TE-11Growth Inhibition Assay2.29473186Sanger
NCI-H2029Growth Inhibition Assay4.941851211Sanger
NCI-H661Growth Inhibition Assay26.47129663Sanger
LOXIMVIGrowth Inhibition Assay86.99824969Sanger
ZR-75-30Growth Inhibition Assay168.4553956Sanger
KINGS-1Growth Inhibition Assay5.077438997Sanger
KLEGrowth Inhibition Assay55.57464099Sanger
SH-4Growth Inhibition Assay76.0193566Sanger
RERF-LC-MSGrowth Inhibition Assay207.2939844Sanger
TE-6Growth Inhibition Assay53.9451074Sanger
NCI-H358Growth Inhibition Assay47.21496984Sanger
LB831-BLCGrowth Inhibition Assay15.27665735Sanger
NCI-H1693Growth Inhibition Assay28.69749969Sanger
SJRH30Growth Inhibition Assay103.7751978Sanger
SW1417Growth Inhibition Assay0.554383829Sanger
IGROV-1Growth Inhibition Assay298.1298113Sanger
SW13Growth Inhibition Assay96.19698344Sanger
A498Growth Inhibition Assay182.33561Sanger
ABC-1Growth Inhibition Assay17.81405941Sanger
ES1Growth Inhibition Assay32.30616245Sanger
HEC-1Growth Inhibition Assay10.3351737Sanger
COLO-741Growth Inhibition Assay97.86735095Sanger
COLO-824Growth Inhibition Assay1.01707921Sanger
CP50-MEL-BGrowth Inhibition Assay9.757819855Sanger
CaR-1Growth Inhibition Assay51.4784874Sanger
BB30-HNCGrowth Inhibition Assay21.27445378Sanger
8305CGrowth Inhibition Assay35.84152007Sanger
769-PGrowth Inhibition Assay3.89510252Sanger
KYSE-150 cell lineGrowth Inhibition Assay91.030444Sanger
NB14Growth Inhibition Assay1.137476259Sanger
Ramos-2G6-4C10Growth Inhibition Assay1.736563222Sanger
U-87 MGGrowth Inhibition Assay209.9623019Sanger
HOP-92Growth Inhibition Assay2.587432316Sanger
HOSGrowth Inhibition Assay67.20233541Sanger
MKN1Growth Inhibition Assay83.81894031Sanger
HSC-2Growth Inhibition Assay9.575502365Sanger
UO-31Growth Inhibition Assay10.59082436Sanger
NCI-H2291Growth Inhibition Assay11.54662285Sanger
LoVoGrowth Inhibition Assay13.23131012Sanger
HCC2157Growth Inhibition Assay1.194938835Sanger
VM-CUB-1Growth Inhibition Assay21.35359266Sanger
PSN1Growth Inhibition Assay41.17486511Sanger
MPP-89Growth Inhibition Assay3.056660561Sanger
PC-14Growth Inhibition Assay131.5726276Sanger
SF126Growth Inhibition Assay8.838648674Sanger
UACC-257Growth Inhibition Assay59.11761889Sanger
UACC-62Growth Inhibition Assay141.1207631Sanger
HCC1395Growth Inhibition Assay34.71858034Sanger
OVCAR-5Growth Inhibition Assay10.6429319Sanger
EW-3Growth Inhibition Assay0.080525289Sanger
HCC2998Growth Inhibition Assay1.071353712Sanger
HD-MY-ZGrowth Inhibition Assay5.239688238Sanger
8505CGrowth Inhibition Assay4.542302309Sanger
A3-KAWGrowth Inhibition Assay73.34856935Sanger
A-431Growth Inhibition Assay18.41274338Sanger
BT-549Growth Inhibition Assay96.69589977Sanger
PFSK-1Growth Inhibition Assay6.05259436Sanger
K5Growth Inhibition Assay45.94054222Sanger
KYSE-510Growth Inhibition Assay71.88955622Sanger
HT-1376Growth Inhibition Assay89.07440218Sanger
HT-144Growth Inhibition Assay75.21690453Sanger
NCI-H1304Growth Inhibition Assay0.46157395Sanger
SN12CGrowth Inhibition Assay11.93547431Sanger
T84Growth Inhibition Assay38.74090428Sanger
HuO-3N1Growth Inhibition Assay2.487795557Sanger
SF295Growth Inhibition Assay10.67038343Sanger
MS-1Growth Inhibition Assay0.469334287Sanger
GB-1Growth Inhibition Assay58.74664236Sanger
DSH1Growth Inhibition Assay45.00326308Sanger
ES4Growth Inhibition Assay1.34997625Sanger
DoTc2-4510Growth Inhibition Assay3.014171501Sanger
GCTGrowth Inhibition Assay7.569060868Sanger
HELGrowth Inhibition Assay1.310289362Sanger

Solubility

Solubility (25°C)* In vitro DMSO 100 mg/mL (102.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.26 mL 51.3 mL 102.61mL
0.5 mM 2.05 mL 10.26 mL 20.52 mL
1 mM 1.03 mL 5.13 mL 10.26 mL
5 mM 0.21 mL 1.03 mL 2.05 mL

*The above data is based on the productmolecular weight 974.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Biological Activity

Phase I study of Navitoclax (ABT-263):

Forty-seven patients, including 29 with small-cell lung cancer (SCLC) or pulmonary carcinoid, were enrolled between 2007 and 2008, 35 on intermittent and 12 on continuous dosing cohorts. Primary toxicities included diarrhea (40%), nausea (34%), vomiting (36%), and fatigue (34%); most were grade 1 or 2. Dose- and schedule-dependent thrombocytopenia was seen in all patients. One patient with SCLC had a confirmed partial response lasting longer than 2 years, and eight patients with SCLC or carcinoid had stable disease (one remained on study for 13 months). Pro-gastrin releasing peptide (pro-GRP) was identified as a surrogate marker of Bcl-2 amplification and changes correlated with changes in tumor volume. CONCLUSION:  Navitoclax is safe and well tolerated, with dose-dependent thrombocytopenia as the major adverse effect. Preliminary efficacy data are encouraging in SCLC. Efficacy in SCLC and the utility of pro-GRP as a marker of treatment response will be further evaluated in phase II studies.

Read More

General References

1. Methods and means for the treatment of cancer using a combination of a BCRP inhibitor and/or a P-gp inhibitor with an imidazotetrazine chemotherapeutic agent By Van Tellingen, Olaf From U.S. Pat. Appl. Publ. (2009), US 20090170880 A1 20090702.
2. Quinazolin-4-ylaminopyrazolecarboxamides as aurora kinase inhibitors useful in bombination therapy for the treatment of cancer and their preparation By Keen, Nicholas John From PCT Int. Appl. (2007), WO 2007132215 A1 20071122.
3. Structure-activity relationships of a series of tariquidar analogs as multidrug resistance modulators By Globisch, Christoph; Pajeva, Ilza K.; Wiese, Michael From Bioorganic & Medicinal Chemistry (2006), 14(5), 1588-1598.
4. Means and methods for treating a disease which is associated with an excess transport of hyaluronan across a lipid bilayer By Prehm, Peter From PCT Int. Appl. (2005), WO 2005013947 A2 20050217.
5. P glycoprotein in human immunodeficiency virus type 1 infection and therapy By Sankatsing, Sanjay U. C.; Beijnen, Jos H.; Schinkel, Alfred H.; Lange, Joep M. A.; Prins, Jan M. From Antimicrobial Agents and Chemotherapy (2004), 48(4), 1073-1081.

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Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10255 ABT-737 <1 mg/mL 163 mg/mL <1 mg/mL
A10022 ABT-263 (Navitoclax) <1 mg/mL 195 mg/mL <1 mg/mL
A10665 Obatoclax mesylate (GX15-070) <1 mg/mL 83 mg/mL <1 mg/mL
A10955 TW-37 <1 mg/mL 115 mg/mL 4 mg/mL
A10984 VX-765 <1 mg/mL 102 mg/mL 102 mg/mL
A11090 PAC-1 <1 mg/mL 78 mg/mL 16 mg/mL
A10491 JNJ 26854165 <1 mg/mL 66 mg/mL 2 mg/mL
A11931 RITA (NSC 652287) <1 mg/mL 115 mg/mL 4 mg/mL
A10522 Lenalidomide (CC-5013) <1 mg/mL 52 mg/mL <1 mg/mL
A10743 Pomalidomide (CC-4047) <1 mg/mL 55 mg/mL <1 mg/mL
A11163 AT-406 <1 mg/mL 112 mg/mL 112 mg/mL
A11002 YM155 89 mg/mL 55 mg/mL 6 mg/mL
A10935 Tipifarnib (Zarnestra) <1 mg/mL 83 mg/mL <1 mg/mL
A10657 Nutlin-3 <1 mg/mL 116 mg/mL 116 mg/mL

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