ABT-263 (Navitoclax)

On Sale
ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). it maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.
Grouped product items
Product Name Price Stock Qty
ABT-263 5mg
Special Price $35.00 Regular Price $50.00
In stock
ABT-263 10mg
Special Price $49.00 Regular Price $70.00
In stock
ABT-263 25mg
Special Price $98.00 Regular Price $140.00
In stock
ABT-263 100mg
Special Price $157.50 Regular Price $225.00
In stock
ABT-263 (Navitoclax) 10mM * 1mL in DMSO
Special Price $56.00 Regular Price $80.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Not your Region? View all Distributors

Adooq Products cited in reputable paper
Adooq's ABT-263 (Navitoclax) has been cited by 24 publications
  • Abdel-Aziz S Shatat, .et al. , Purinergic Signal, 2024, May 27 PMID: 38801618
  • Tristen Wright, .et al. , Mol Cell, 2024, Apr 4;84(7):1338-1353 PMID: 38503284
  • Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418
  • Yibo Wen, .et al. , Ren Fail, 2023, Dec;45(1):2194440 PMID: 37154092
  • Rindert Missiaen, .et al. , Cell Metab, 2022, Aug 2;34(8):1151-1167 PMID: 35839757
  • Ashlyn Parkhurst, .et al. , Cell Death Dis, 2022, Apr 28;13(4):410 PMID: 35484114
  • Suzuki, Keiji, .et al. , Mutat Res Genet Toxicol Environ Mutagen, 2022, 876-877. 503448
  • Rotem Ben-Hamo, .et al. , Nat Commun, 2020, 11: 3296
  • Hua Xu, .et al. , Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
  • Hiroki Akiyama, .et al. , Cancers, 2020, 12 (2) PMID: 32050632
  • Stephanie Ketterer, .et al. , Nat Commun, 2020, Oct 12;11(1):5133 PMID: 33046706
  • Makoto Koyama, .et al. , Int J Oncol, 2020, Sep 2 PMID: 32901840
  • Min Li, .et al. , Nat Commun, 2020, 11: 4051 PMID: 32792548
  • Hamzehlou S, .et al. , Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
  • Momeny M, .et al. , Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
  • Anderson R, .et al. , EMBO J, 2019, Feb 8. pii: e100492 PMID: 30737259
  • Shinya Ishida, .et al. , Oncotarget, 2018, Jun 1; 9(42): 26834-26851 PMID: 29928488
  • Rhys Anderson, .et al. , bioRxiv, 2018, 2018
  • Ryuta Mikawa, .et al. , Aging Cell, 2018, Oct; 17(5): e12827 PMID: 30058137
  • Joo Sang Lee, .et al. , Nat Commun, 2018, 9: 2546 PMID: 29959327
  • Toshiyuki Sumi, .et al. , Int J Oncol, 2018, Jul; 53(1): 33-46 PMID: 29658609
  • Wei TW, .et al. , Cancer Res, 2017, Jan 15;77(2):494-508 PMID: 28069801
  • Yusuke Takagi, .et al. , Cancer Sci, 2016, Sep; 107(9): 1270-1280 PMID: 27348272
  • Matsumoto M, .et al. , Biochem Biophys Res Commun, 2016, Apr 29;473(2):490-6 PMID: 26996126
  • Biological Activity
    Discription
    ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). it maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.
    Targets
    Target Value
    Product Information
    Catalog Num A10022
    Formula C47H55ClF3N5O6S3
    Molecular Weight 974.6
    CAS Number 923564-51-6
    SMILES CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
    Synonyms ABT263
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 89 mg/mL (91.31 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+corn oil 6 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 10.26 mL 51.3 mL 102.61 mL
    0.5 mM 2.05 mL 10.26 mL 20.52 mL
    1 mM 1.03 mL 5.13 mL 10.26 mL
    5 mM 0.21 mL 1.03 mL 2.05 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

      Concentration

      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

      V1

      C2

      V2

    • Calculator Reset
    Keywords: buy ABT-263 (Navitoclax) | ABT-263 (Navitoclax) Supplier | purchase ABT-263 (Navitoclax) | ABT-263 (Navitoclax) cost | ABT-263 (Navitoclax) manufacturer | order ABT-263 (Navitoclax) | ABT-263 (Navitoclax) distributor | buy 923564-51-6 | 923564-51-6 Supplier | purchase 923564-51-6 | 923564-51-6 cost | 923564-51-6 manufacturer | order 923564-51-6 | 923564-51-6 distributor