- Rotem Ben-Hamo, .et al. Predicting and affecting response to cancer therapy based on pathway-level biomarkers, Nat Commun, 2020, 11: 3296
- Hua Xu, .et al. Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation, Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
- Hiroki Akiyama, .et al. Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically With BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells, Cancers, 2020, 12 (2) PMID: 32050632
- Stephanie Ketterer, .et al. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling, Nat Commun, 2020, Oct 12;11(1):5133 PMID: 33046706
- Makoto Koyama, .et al. Low-dose trametinib and Bcl-xL antagonist have a specific antitumor effect in KRAS-mutated colorectal cancer cells, Int J Oncol, 2020, Sep 2 PMID: 32901840
- Min Li, .et al. Clearance of HIV infection by selective elimination of host cells capable of producing HIV, Nat Commun, 2020, 11: 4051 PMID: 32792548
- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Momeny M, .et al. The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells, Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
- Anderson R, .et al. Length-independent telomere damage drives postmitotic cardiomyocyte senescence, EMBO J, 2019, Feb 8. pii: e100492 PMID: 30737259
- Shinya Ishida, .et al. Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2, Oncotarget, 2018, Jun 1; 9(42): 26834-26851 PMID: 29928488
- Rhys Anderson, .et al. Length-independent telomere damage drives cardiomyocyte senescence, bioRxiv, 2018, 2018
- Ryuta Mikawa, .et al. Elimination of p19ARF?\expressing cells protects against pulmonary emphysema in mice, Aging Cell, 2018, Oct; 17(5): e12827 PMID: 30058137
- Joo Sang Lee, .et al. Harnessing synthetic lethality to predict the response to cancer treatment, Nat Commun, 2018, 9: 2546 PMID: 29959327
- Toshiyuki Sumi, .et al. Survivin knockdown induces senescence in TTF-1-expressing, KRAS-mutant lung adenocarcinomas, Int J Oncol, 2018, Jul; 53(1): 33-46 PMID: 29658609
- Wei TW, .et al. Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA, Cancer Res, 2017, Jan 15;77(2):494-508 PMID: 28069801
- Yusuke Takagi, .et al. SPIB is a novel prognostic factor in diffuse large B?\cell lymphoma that mediates apoptosis via the PI3K-AKT pathway, Cancer Sci, 2016, Sep; 107(9): 1270-1280 PMID: 27348272
- Matsumoto M, .et al. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells, Biochem Biophys Res Commun, 2016, Apr 29;473(2):490-6 PMID: 26996126
Biological Activity
ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). it maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.
Targets
Bcl-xL (Cell-free assay)[1] | Bcl-2 (Cell-free assay) | Bcl-w (Cell-free assay) | A1 (Cell-free assay) | Mcl-1 (Cell-free assay) |
<=0.5 nM(Ki) | <=1 nM(Ki) | <=1 nM(Ki) | 354 nM(Ki) | 550 nM(Ki) |
Cell data
Cell Lines | Assay Type | Activity (IC50 μM) | Source |
---|---|---|---|
MHH-NB-11 | Growth Inhibition Assay | 2.511582418 | Sanger |
TYK-nu | Growth Inhibition Assay | 30.03444831 | Sanger |
GMS-10 | Growth Inhibition Assay | 26.86380926 | Sanger |
HN | Growth Inhibition Assay | 15.59421481 | Sanger |
KYSE-140 | Growth Inhibition Assay | 131.1040129 | Sanger |
J82 | Growth Inhibition Assay | 8.900380245 | Sanger |
SW900 | Growth Inhibition Assay | 21.01492711 | Sanger |
RT-112 | Growth Inhibition Assay | 20.61217664 | Sanger |
NCI-H747 | Growth Inhibition Assay | 238.4429313 | Sanger |
KYSE-180 | Growth Inhibition Assay | 61.94438708 | Sanger |
SW1783 | Growth Inhibition Assay | 7.431747305 | Sanger |
IST-MES1 | Growth Inhibition Assay | 108.9812664 | Sanger |
GI-ME-N | Growth Inhibition Assay | 229.4467554 | Sanger |
T47D | Growth Inhibition Assay | 115.0095306 | Sanger |
NCI-H2228 | Growth Inhibition Assay | 14.60765929 | Sanger |
NCI-H226 | Growth Inhibition Assay | 162.2398831 | Sanger |
SNU1 | Growth Inhibition Assay | 1.365546889 | Sanger |
EW-11 | Growth Inhibition Assay | 1.956570117 | Sanger |
EW-13 | Growth Inhibition Assay | 0.583409464 | Sanger |
KARPAS-45 | Growth Inhibition Assay | 0.078148298 | Sanger |
NCI-H1299 | Growth Inhibition Assay | 119.1909704 | Sanger |
ETK-1 | Growth Inhibition Assay | 39.02197699 | Sanger |
KYSE-520 cell line | Growth Inhibition Assay | 25.64400959 | Sanger |
LU-139 | Growth Inhibition Assay | 0.204980997 | Sanger |
COLO-829 | Growth Inhibition Assay | 85.88962142 | Sanger |
CAL-39 | Growth Inhibition Assay | 72.1986249 | Sanger |
A704 | Growth Inhibition Assay | 0.426701318 | Sanger |
C2BBe1 | Growth Inhibition Assay | 4.740084678 | Sanger |
BALL-1 | Growth Inhibition Assay | 47.61676952 | Sanger |
Ca-Ski | Growth Inhibition Assay | 7.993830047 | Sanger |
CAL-62 | Growth Inhibition Assay | 115.0576147 | Sanger |
ChaGo-K-1 | Growth Inhibition Assay | 58.06697002 | Sanger |
CW-2 | Growth Inhibition Assay | 56.69698303 | Sanger |
639-V | Growth Inhibition Assay | 52.1621429 | Sanger |
BB65-RCC | Growth Inhibition Assay | 4.043994738 | Sanger |
8-MG-BA | Growth Inhibition Assay | 152.2964576 | Sanger |
CHL-1 | Growth Inhibition Assay | 121.5359374 | Sanger |
CAS-1 | Growth Inhibition Assay | 132.4120962 | Sanger |
G-401 | Growth Inhibition Assay | 260.4922213 | Sanger |
JVM-3 | Growth Inhibition Assay | 4.182223321 | Sanger |
MN-60 | Growth Inhibition Assay | 11.53903921 | Sanger |
NCI-H82 | Growth Inhibition Assay | 3.959362391 | Sanger |
NCI-H1048 | Growth Inhibition Assay | 0.509532317 | Sanger |
ES7 | Growth Inhibition Assay | 1.279505916 | Sanger |
SW837 | Growth Inhibition Assay | 15.78468238 | Sanger |
SW872 | Growth Inhibition Assay | 15.30860364 | Sanger |
BT-474 | Growth Inhibition Assay | 136.2733779 | Sanger |
NCI-H650 | Growth Inhibition Assay | 183.1777513 | Sanger |
OE19 | Growth Inhibition Assay | 5.686244428 | Sanger |
EM-2 | Growth Inhibition Assay | 0.19917947 | Sanger |
D-392MG | Growth Inhibition Assay | 255.4235123 | Sanger |
BPH-1 | Growth Inhibition Assay | 18.16845775 | Sanger |
D-423MG | Growth Inhibition Assay | 226.0018082 | Sanger |
COLO-668 | Growth Inhibition Assay | 6.843867529 | Sanger |
HuP-T4 | Growth Inhibition Assay | 17.24944553 | Sanger |
MDA-MB-415 | Growth Inhibition Assay | 1.388499961 | Sanger |
KNS-62 | Growth Inhibition Assay | 16.97768781 | Sanger |
SW1088 | Growth Inhibition Assay | 103.6042135 | Sanger |
NCI-H1650 | Growth Inhibition Assay | 2.722149975 | Sanger |
NCI-H1651 | Growth Inhibition Assay | 86.97032774 | Sanger |
NCI-H446 | Growth Inhibition Assay | 6.62925215 | Sanger |
NCI-H460 | Growth Inhibition Assay | 182.5881372 | Sanger |
TE-9 | Growth Inhibition Assay | 47.95811376 | Sanger |
GAMG | Growth Inhibition Assay | 10.51615872 | Sanger |
IA-LM | Growth Inhibition Assay | 5.398709805 | Sanger |
MZ7-mel | Growth Inhibition Assay | 148.9475157 | Sanger |
KOSC-2 | Growth Inhibition Assay | 72.12494772 | Sanger |
OAW-42 | Growth Inhibition Assay | 0.961459343 | Sanger |
OC-314 | Growth Inhibition Assay | 49.6834063 | Sanger |
HDLM-2 | Growth Inhibition Assay | 33.69313138 | Sanger |
TE-10 | Growth Inhibition Assay | 196.765566 | Sanger |
RD | Growth Inhibition Assay | 0.758985201 | Sanger |
NCI-H292 | Growth Inhibition Assay | 25.35358145 | Sanger |
RCC10RGB | Growth Inhibition Assay | 8.995612874 | Sanger |
MDA-MB-231 | Growth Inhibition Assay | 121.4292757 | Sanger |
HuCCT1 | Growth Inhibition Assay | 115.261908 | Sanger |
MCF7 | Growth Inhibition Assay | 45.50512696 | Sanger |
T98G | Growth Inhibition Assay | 18.51566258 | Sanger |
NCI-H1581 | Growth Inhibition Assay | 2.796811449 | Sanger |
EW-18 | Growth Inhibition Assay | 0.068406187 | Sanger |
LB1047-RCC | Growth Inhibition Assay | 6.476252337 | Sanger |
SNU-387 | Growth Inhibition Assay | 66.49149202 | Sanger |
SW1710 | Growth Inhibition Assay | 30.12604259 | Sanger |
J-RT3-T3-5 | Growth Inhibition Assay | 0.608082935 | Sanger |
SW1990 | Growth Inhibition Assay | 4.059078592 | Sanger |
No Data | Growth Inhibition Assay | 0.5 | Scientific Literature |
NCI-H187 | Growth Inhibition Assay | 38.4 | Scientific Literature |
EOL1 | Growth Inhibition Assay | 0.006693449 | Sanger |
NOS-1 | Growth Inhibition Assay | 3.798343308 | Sanger |
HCE-4 | Growth Inhibition Assay | 110.5017104 | Sanger |
RH-1 | Growth Inhibition Assay | 97.18749005 | Sanger |
OVCAR-4 | Growth Inhibition Assay | 16.8862385 | Sanger |
JVM-2 | Growth Inhibition Assay | 240.5175356 | Sanger |
DU-4475 | Growth Inhibition Assay | 0.65427011 | Sanger |
BV-173 | Growth Inhibition Assay | 0.023136912 | Sanger |
NCI-H2030 | Growth Inhibition Assay | 47.23740228 | Sanger |
LS-1034 | Growth Inhibition Assay | 107.2310658 | Sanger |
TGBC24TKB | Growth Inhibition Assay | 0.457775678 | Sanger |
U-118-MG | Growth Inhibition Assay | 2.964910955 | Sanger |
OVCAR-8 | Growth Inhibition Assay | 27.06382594 | Sanger |
MG-63 | Growth Inhibition Assay | 211.0029259 | Sanger |
K-562 | Growth Inhibition Assay | 50.68059015 | Sanger |
MKN28 | Growth Inhibition Assay | 33.38093738 | Sanger |
KYSE-410 | Growth Inhibition Assay | 16.59101029 | Sanger |
LU-134-A | Growth Inhibition Assay | 0.186705457 | Sanger |
ESS-1 | Growth Inhibition Assay | 5.255972242 | Sanger |
HAL-01 | Growth Inhibition Assay | 0.72548564 | Sanger |
COLO-678 | Growth Inhibition Assay | 65.2431461 | Sanger |
RPMI-8866 | Growth Inhibition Assay | 17.17318233 | Sanger |
GI-1 | Growth Inhibition Assay | 5.279255057 | Sanger |
T-24 | Growth Inhibition Assay | 17.53468641 | Sanger |
UMC-11 | Growth Inhibition Assay | 4.889636669 | Sanger |
NCI-H1623 | Growth Inhibition Assay | 4.702282363 | Sanger |
HCC70 | Growth Inhibition Assay | 32.13867071 | Sanger |
MOLT-13 | Growth Inhibition Assay | 0.466129867 | Sanger |
HCC2218 | Growth Inhibition Assay | 38.65186394 | Sanger |
KG-1 | Growth Inhibition Assay | 0.044862725 | Sanger |
KGN | Growth Inhibition Assay | 183.8231217 | Sanger |
LXF-289 cell line | Growth Inhibition Assay | 5.037188051 | Sanger |
MOLT-4 | Growth Inhibition Assay | 0.151693537 | Sanger |
MC-IXC | Growth Inhibition Assay | 12.75183267 | Sanger |
SF-268 | Growth Inhibition Assay | 126.1987443 | Sanger |
ME-180 | Growth Inhibition Assay | 12.70543685 | Sanger |
SW1116 | Growth Inhibition Assay | 37.59917091 | Sanger |
SW1573 | Growth Inhibition Assay | 52.63156317 | Sanger |
MeWo | Growth Inhibition Assay | 20.12876728 | Sanger |
ACN | Growth Inhibition Assay | 40.49105154 | Sanger |
C3A | Growth Inhibition Assay | 226.9046761 | Sanger |
DMS-273 | Growth Inhibition Assay | 82.20433188 | Sanger |
CAL-12T | Growth Inhibition Assay | 39.52806793 | Sanger |
Calu-3 | Growth Inhibition Assay | 1.70696681 | Sanger |
CHP-212 | Growth Inhibition Assay | 3.925485351 | Sanger |
NCI-H23 | Growth Inhibition Assay | 21.12772164 | Sanger |
DK-MG | Growth Inhibition Assay | 77.50287249 | Sanger |
A388 | Growth Inhibition Assay | 1.687244964 | Sanger |
BHY | Growth Inhibition Assay | 18.86897427 | Sanger |
Becker | Growth Inhibition Assay | 55.52931059 | Sanger |
SW780 | Growth Inhibition Assay | 6.701845927 | Sanger |
MHH-ES-1 | Growth Inhibition Assay | 8.518335859 | Sanger |
786-0 | Growth Inhibition Assay | 121.43304 | Sanger |
BCPAP | Growth Inhibition Assay | 4.634809046 | Sanger |
BFTC-909 | Growth Inhibition Assay | 103.8793365 | Sanger |
CCRF-CEM | Growth Inhibition Assay | 0.33528881 | Sanger |
MFE-280 | Growth Inhibition Assay | 2.028482548 | Sanger |
OCI-AML2 | Growth Inhibition Assay | 3.312721311 | Sanger |
NCI-H2452 | Growth Inhibition Assay | 49.11522165 | Sanger |
HT-1197 | Growth Inhibition Assay | 60.31042655 | Sanger |
PA-1 | Growth Inhibition Assay | 0.956418213 | Sanger |
PANC-03-27 | Growth Inhibition Assay | 22.5169194 | Sanger |
PANC-08-13 | Growth Inhibition Assay | 3.634723347 | Sanger |
SCC-25 | Growth Inhibition Assay | 11.75555624 | Sanger |
L-428 | Growth Inhibition Assay | 1.012497449 | Sanger |
UMUC3 | Growth Inhibition Assay | 75.54949467 | Sanger |
S-117 | Growth Inhibition Assay | 142.7695797 | Sanger |
NCI-H1155 | Growth Inhibition Assay | 5.549550869 | Sanger |
HT-1080 | Growth Inhibition Assay | 9.777394133 | Sanger |
NCI-H2347 | Growth Inhibition Assay | 12.76142565 | Sanger |
NCI-H1963 | Growth Inhibition Assay | 26.6 | Scientific Literature |
COLO-680N | Growth Inhibition Assay | 25.63290814 | Sanger |
KP-N-YS | Growth Inhibition Assay | 1.162358348 | Sanger |
NCI-H1792 | Growth Inhibition Assay | 17.79798057 | Sanger |
KNS-81-FD | Growth Inhibition Assay | 0.440174077 | Sanger |
MEG-01 | Growth Inhibition Assay | 0.583203557 | Sanger |
SJSA-1 | Growth Inhibition Assay | 41.15959207 | Sanger |
SKG-IIIa | Growth Inhibition Assay | 7.818916578 | Sanger |
RPMI-2650 | Growth Inhibition Assay | 5.361603013 | Sanger |
ATN-1 | Growth Inhibition Assay | 0.047333499 | Sanger |
Calu-6 | Growth Inhibition Assay | 4.278810284 | Sanger |
647-V | Growth Inhibition Assay | 71.9701896 | Sanger |
CHP-134 | Growth Inhibition Assay | 0.16305691 | Sanger |
DOK | Growth Inhibition Assay | 56.23250666 | Sanger |
HH | Growth Inhibition Assay | 3.83867786 | Sanger |
GR-ST | Growth Inhibition Assay | 117.7714639 | Sanger |
NCI-H1838 | Growth Inhibition Assay | 60.2159339 | Sanger |
LN-405 | Growth Inhibition Assay | 158.3525696 | Sanger |
ES5 | Growth Inhibition Assay | 4.139847701 | Sanger |
EFO-21 | Growth Inhibition Assay | 77.13483544 | Sanger |
DU-145 | Growth Inhibition Assay | 0.899231293 | Sanger |
AN3-CA | Growth Inhibition Assay | 3.442383124 | Sanger |
D283 Med | Growth Inhibition Assay | 0.176862975 | Sanger |
MDA-MB-361 | Growth Inhibition Assay | 71.82344825 | Sanger |
NUGC-3 | Growth Inhibition Assay | 7.396937033 | Sanger |
LB996-RCC | Growth Inhibition Assay | 9.198900812 | Sanger |
VA-ES-BJ | Growth Inhibition Assay | 12.87849673 | Sanger |
HCC1937 | Growth Inhibition Assay | 6.992512963 | Sanger |
HT-29 | Growth Inhibition Assay | 166.276988 | Sanger |
EW-22 | Growth Inhibition Assay | 0.466705893 | Sanger |
KE-37 | Growth Inhibition Assay | 0.113696234 | Sanger |
NCI-H1755 | Growth Inhibition Assay | 149.5793468 | Sanger |
NCI-H522 | Growth Inhibition Assay | 15.3305566 | Sanger |
IST-MEL1 | Growth Inhibition Assay | 21.3691651 | Sanger |
NY | Growth Inhibition Assay | 57.95216912 | Sanger |
IGR-1 | Growth Inhibition Assay | 2.62034503 | Sanger |
LS-513 | Growth Inhibition Assay | 143.5215216 | Sanger |
NCI-H2122 | Growth Inhibition Assay | 26.99978762 | Sanger |
SK-PN-DW | Growth Inhibition Assay | 21.16487568 | Sanger |
KALS-1 | Growth Inhibition Assay | 48.12890826 | Sanger |
SiHa | Growth Inhibition Assay | 97.99740512 | Sanger |
NCI-H2126 | Growth Inhibition Assay | 7.736249427 | Sanger |
NCI-H1092 | Growth Inhibition Assay | 0.10275251 | Sanger |
L-363 | Growth Inhibition Assay | 13.40330073 | Sanger |
SNU-449 | Growth Inhibition Assay | 61.57500345 | Sanger |
HCC38 | Growth Inhibition Assay | 0.801903502 | Sanger |
LB2518-MEL | Growth Inhibition Assay | 16.83888845 | Sanger |
KM12 | Growth Inhibition Assay | 36.75473276 | Sanger |
SNU-C2B | Growth Inhibition Assay | 43.68780494 | Sanger |
YKG-1 | Growth Inhibition Assay | 76.14222705 | Sanger |
AM-38 | Growth Inhibition Assay | 13.25663259 | Sanger |
CAMA-1 | Growth Inhibition Assay | 20.98030205 | Sanger |
AGS | Growth Inhibition Assay | 10.37395149 | Sanger |
BHT-101 | Growth Inhibition Assay | 10.71769378 | Sanger |
CGTH-W-1 | Growth Inhibition Assay | 17.52187324 | Sanger |
C32 | Growth Inhibition Assay | 1.19088056 | Sanger |
COLO-800 | Growth Inhibition Assay | 39.38677106 | Sanger |
no-11 | Growth Inhibition Assay | 4.355541751 | Sanger |
D-502MG | Growth Inhibition Assay | 73.00821726 | Sanger |
D-566MG | Growth Inhibition Assay | 41.20860114 | Sanger |
ES3 | Growth Inhibition Assay | 4.354409457 | Sanger |
EFM-19 | Growth Inhibition Assay | 3.483390148 | Sanger |
EKVX | Growth Inhibition Assay | 20.6059733 | Sanger |
DEL | Growth Inhibition Assay | 1.746923079 | Sanger |
A673 | Growth Inhibition Assay | 84.40865975 | Sanger |
SHP-77 | Growth Inhibition Assay | 77.74583652 | Sanger |
UACC-893 | Growth Inhibition Assay | 27.98783636 | Sanger |
NB13 | Growth Inhibition Assay | 0.082027313 | Sanger |
SK-MEL-28 | Growth Inhibition Assay | 9.618929693 | Sanger |
LS-123 | Growth Inhibition Assay | 99.61502434 | Sanger |
KU812 cell line | Growth Inhibition Assay | 19.95730018 | Sanger |
NCI-H727 | Growth Inhibition Assay | 20.27036566 | Sanger |
MIA PaCa-2 | Growth Inhibition Assay | 122.9329396 | Sanger |
SW948 | Growth Inhibition Assay | 47.46402236 | Sanger |
NCI-H69 | Growth Inhibition Assay | 12.42342744 | Sanger |
NB69 | Growth Inhibition Assay | 1.462707251 | Sanger |
ES8 | Growth Inhibition Assay | 2.254713694 | Sanger |
H4 | Growth Inhibition Assay | 221.9233385 | Sanger |
H9 | Growth Inhibition Assay | 3.671440163 | Sanger |
RPMI-8226 | Growth Inhibition Assay | 0.456518981 | Sanger |
SK-MEL-1 | Growth Inhibition Assay | 38.33893655 | Sanger |
SW48 | Growth Inhibition Assay | 10.51889328 | Sanger |
NB5 | Growth Inhibition Assay | 13.37518334 | Sanger |
FDC-P1 | Growth Inhibition Assay | 0.06 | Scientific Literature |
NCI-H1563 | Growth Inhibition Assay | 14.60393481 | Sanger |
SNU-423 | Growth Inhibition Assay | 1.781571785 | Sanger |
NKM-1 | Growth Inhibition Assay | 0.016985555 | Sanger |
NOMO-1 | Growth Inhibition Assay | 6.78111132 | Sanger |
HuO9 | Growth Inhibition Assay | 0.267145453 | Sanger |
MV-4-11 | Growth Inhibition Assay | 0.01585648 | Sanger |
NCI-H2170 | Growth Inhibition Assay | 1.062297484 | Sanger |
NCI-H1573 | Growth Inhibition Assay | 171.6787504 | Sanger |
SBC-1 | Growth Inhibition Assay | 1.190534064 | Sanger |
NCI-H810 | Growth Inhibition Assay | 60.65596611 | Sanger |
HSC-3 | Growth Inhibition Assay | 1.963651991 | Sanger |
SCC-9 | Growth Inhibition Assay | 15.81138104 | Sanger |
MKN7 | Growth Inhibition Assay | 15.97316298 | Sanger |
KYSE-450 | Growth Inhibition Assay | 82.00399782 | Sanger |
EW-16 | Growth Inhibition Assay | 0.813279858 | Sanger |
HCC1954 | Growth Inhibition Assay | 81.0700017 | Sanger |
LAMA-84 | Growth Inhibition Assay | 0.592073202 | Sanger |
NBsusSR | Growth Inhibition Assay | 3.349379149 | Sanger |
SK-MES-1 | Growth Inhibition Assay | 176.4423157 | Sanger |
RVH-421 | Growth Inhibition Assay | 3.568770005 | Sanger |
RXF393 | Growth Inhibition Assay | 68.64010604 | Sanger |
U-2-OS | Growth Inhibition Assay | 5.890129595 | Sanger |
KYSE-270 | Growth Inhibition Assay | 74.46282444 | Sanger |
SW 954 | Growth Inhibition Assay | 4.296595651 | Sanger |
SW982 | Growth Inhibition Assay | 145.2470376 | Sanger |
HTC-C3 | Growth Inhibition Assay | 22.55545627 | Sanger |
M14 | Growth Inhibition Assay | 110.8608709 | Sanger |
NB6 | Growth Inhibition Assay | 4.8620395 | Sanger |
NCI-H2052 | Growth Inhibition Assay | 1.722013077 | Sanger |
NCI-H2087 | Growth Inhibition Assay | 31.6352182 | Sanger |
NCI-H209 | Growth Inhibition Assay | 0.087038041 | Sanger |
NCI-H720 | Growth Inhibition Assay | 0.040110465 | Sanger |
RS4-11 | Growth Inhibition Assay | 0.025873992 | Sanger |
LS-411N | Growth Inhibition Assay | 184.5698532 | Sanger |
OS-RC-2 | Growth Inhibition Assay | 5.52603743 | Sanger |
FTC-133 | Growth Inhibition Assay | 4.539500573 | Sanger |
Huh-7 | Growth Inhibition Assay | 1.672932375 | Sanger |
G-402 | Growth Inhibition Assay | 5.518654055 | Sanger |
HCT-116 | Growth Inhibition Assay | 161.9136227 | Sanger |
LB2241-RCC | Growth Inhibition Assay | 9.191369997 | Sanger |
NTERA-2-cl-D1 | Growth Inhibition Assay | 0.500187625 | Sanger |
LB771-HNC | Growth Inhibition Assay | 109.2516569 | Sanger |
MZ1-PC | Growth Inhibition Assay | 107.3875228 | Sanger |
MZ2-MEL | Growth Inhibition Assay | 141.5245217 | Sanger |
SNU-5 | Growth Inhibition Assay | 56.48488047 | Sanger |
GAK | Growth Inhibition Assay | 288.1807824 | Sanger |
TE-8 | Growth Inhibition Assay | 23.25648458 | Sanger |
Mo-T | Growth Inhibition Assay | 4.04312133 | Sanger |
KP-4 | Growth Inhibition Assay | 5.463343691 | Sanger |
LC-2-ad | Growth Inhibition Assay | 4.295684869 | Sanger |
LCLC-103H cell line | Growth Inhibition Assay | 22.15820817 | Sanger |
MLMA | Growth Inhibition Assay | 1.966774714 | Sanger |
MMAC-SF | Growth Inhibition Assay | 9.687496177 | Sanger |
RH-18 | Growth Inhibition Assay | 0.060478279 | Sanger |
HCC1569 | Growth Inhibition Assay | 0.251056065 | Sanger |
SK-UT-1 | Growth Inhibition Assay | 9.049450159 | Sanger |
Lu-65 | Growth Inhibition Assay | 93.07410465 | Sanger |
HCC1419 | Growth Inhibition Assay | 4.900631136 | Sanger |
OAW-28 | Growth Inhibition Assay | 0.78370469 | Sanger |
LU-99A | Growth Inhibition Assay | 146.6686557 | Sanger |
TGBC11TKB | Growth Inhibition Assay | 2.576814639 | Sanger |
JEG-3 | Growth Inhibition Assay | 88.53898823 | Sanger |
KY821 | Growth Inhibition Assay | 0.029747595 | Sanger |
EGI-1 | Growth Inhibition Assay | 42.4280203 | Sanger |
ECC10 | Growth Inhibition Assay | 0.037924611 | Sanger |
CAKI-1 | Growth Inhibition Assay | 119.3213173 | Sanger |
CAL-54 | Growth Inhibition Assay | 31.72411128 | Sanger |
BB49-HNC | Growth Inhibition Assay | 70.80318602 | Sanger |
CAL-85-1 | Growth Inhibition Assay | 66.98729671 | Sanger |
CAPAN-1 | Growth Inhibition Assay | 7.773565971 | Sanger |
CTV-1 | Growth Inhibition Assay | 9.565319449 | Sanger |
ACHN | Growth Inhibition Assay | 11.4210712 | Sanger |
CWR22R | Growth Inhibition Assay | 149.9176285 | Sanger |
C8166 | Growth Inhibition Assay | 28.69382664 | Sanger |
CTB-1 | Growth Inhibition Assay | 21.47548388 | Sanger |
A101D | Growth Inhibition Assay | 69.07749567 | Sanger |
BE-13 | Growth Inhibition Assay | 0.364586297 | Sanger |
D-263MG | Growth Inhibition Assay | 119.5289976 | Sanger |
D-336MG | Growth Inhibition Assay | 116.0415133 | Sanger |
A2058 | Growth Inhibition Assay | 12.8680565 | Sanger |
A253 | Growth Inhibition Assay | 124.6739588 | Sanger |
A2780 | Growth Inhibition Assay | 51.02909703 | Sanger |
BFTC-905 | Growth Inhibition Assay | 54.06672868 | Sanger |
A172 | Growth Inhibition Assay | 178.9934119 | Sanger |
SW626 | Growth Inhibition Assay | 3.245430477 | Sanger |
HL-60 | Growth Inhibition Assay | 0.029084177 | Sanger |
KS-1 | Growth Inhibition Assay | 17.67296375 | Sanger |
SK-MEL-30 | Growth Inhibition Assay | 14.06452965 | Sanger |
TGW | Growth Inhibition Assay | 0.046325718 | Sanger |
Aspc-1 | Growth Inhibition Assay | 19.86572729 | Sanger |
NCI-H1355 | Growth Inhibition Assay | 33.20405477 | Sanger |
NCI-H1395 | Growth Inhibition Assay | 100.2298451 | Sanger |
No Data | Growth Inhibition Assay | 4.3 | Scientific Literature |
DJM-1 | Growth Inhibition Assay | 27.14535649 | Sanger |
CAL-120 | Growth Inhibition Assay | 1.164289465 | Sanger |
BEN | Growth Inhibition Assay | 0.239677982 | Sanger |
D-247MG | Growth Inhibition Assay | 1.51121959 | Sanger |
NCI-H2342 | Growth Inhibition Assay | 1.402694458 | Sanger |
DOHH-2 | Growth Inhibition Assay | 0.410232175 | Sanger |
YH-13 | Growth Inhibition Assay | 8.610083359 | Sanger |
QIMR-WIL | Growth Inhibition Assay | 0.042865027 | Sanger |
Panc1005 | Growth Inhibition Assay | 34.10141913 | Sanger |
RCM-1 | Growth Inhibition Assay | 2.003993621 | Sanger |
TE-1 | Growth Inhibition Assay | 136.3801218 | Sanger |
COLO-684 | Growth Inhibition Assay | 8.018184302 | Sanger |
DB | Growth Inhibition Assay | 0.57080422 | Sanger |
COLO-320-HSR | Growth Inhibition Assay | 7.227382952 | Sanger |
KM-H2 | Growth Inhibition Assay | 64.33198877 | Sanger |
TE-12 | Growth Inhibition Assay | 8.59931028 | Sanger |
COLO-792 | Growth Inhibition Assay | 1.200708741 | Sanger |
A549 | Growth Inhibition Assay | 130.4844418 | Sanger |
BXPC-3 | Growth Inhibition Assay | 81.1668571 | Sanger |
C-33-A | Growth Inhibition Assay | 85.31420751 | Sanger |
VMRC-RCZ | Growth Inhibition Assay | 11.32008974 | Sanger |
WM-115 | Growth Inhibition Assay | 0.277379964 | Sanger |
NEC8 | Growth Inhibition Assay | 6.766297234 | Sanger |
NB7 | Growth Inhibition Assay | 198.3553264 | Sanger |
KP-N-YN | Growth Inhibition Assay | 0.235727925 | Sanger |
RO82-W-1 | Growth Inhibition Assay | 64.45104865 | Sanger |
MEL-HO | Growth Inhibition Assay | 7.770542642 | Sanger |
GCIY | Growth Inhibition Assay | 3.204906767 | Sanger |
HGC-27 | Growth Inhibition Assay | 87.99948833 | Sanger |
NCI-H520 | Growth Inhibition Assay | 192.3458397 | Sanger |
HCE-T | Growth Inhibition Assay | 7.877834055 | Sanger |
HuP-T3 | Growth Inhibition Assay | 74.61100377 | Sanger |
TE-5 | Growth Inhibition Assay | 3.707085543 | Sanger |
MDA-MB-453 | Growth Inhibition Assay | 186.2289815 | Sanger |
NCI-H1666 | Growth Inhibition Assay | 82.202359 | Sanger |
no-10 | Growth Inhibition Assay | 107.4347837 | Sanger |
NCI-H441 | Growth Inhibition Assay | 20.00099455 | Sanger |
SW1463 | Growth Inhibition Assay | 44.99705306 | Sanger |
PC-3 | Growth Inhibition Assay | 157.4078173 | Sanger |
HT55 | Growth Inhibition Assay | 108.6020192 | Sanger |
HT-3 | Growth Inhibition Assay | 17.59136224 | Sanger |
P12-Ichikawa | Growth Inhibition Assay | 0.077783341 | Sanger |
SK-N-DZ | Growth Inhibition Assay | 16.61157929 | Sanger |
P30-OHK | Growth Inhibition Assay | 1.046884908 | Sanger |
SAS | Growth Inhibition Assay | 34.45651175 | Sanger |
SW962 | Growth Inhibition Assay | 65.19670951 | Sanger |
ML-2 | Growth Inhibition Assay | 0.019825486 | Sanger |
HT | Growth Inhibition Assay | 188.6599145 | Sanger |
KARPAS-299 | Growth Inhibition Assay | 3.673614299 | Sanger |
5637 | Growth Inhibition Assay | 3.611029819 | Sanger |
COR-L88 | Growth Inhibition Assay | 0.365401328 | Sanger |
NCI-H28 | Growth Inhibition Assay | 226.5781685 | Sanger |
IST-SL1 | Growth Inhibition Assay | 0.353434889 | Sanger |
NB12 | Growth Inhibition Assay | 0.231150099 | Sanger |
OMC-1 | Growth Inhibition Assay | 1.86016278 | Sanger |
SK-HEP-1 | Growth Inhibition Assay | 135.2282376 | Sanger |
A-427 | Growth Inhibition Assay | 0.930222011 | Sanger |
HMV-2 cell line | Growth Inhibition Assay | 31.35917852 | Sanger |
KU-19-19 | Growth Inhibition Assay | 91.75142333 | Sanger |
MFM-223 | Growth Inhibition Assay | 15.18129382 | Sanger |
A4-Fuk | Growth Inhibition Assay | 188.4153812 | Sanger |
RPMI-7951 | Growth Inhibition Assay | 4.224128638 | Sanger |
SK-MEL-3 | Growth Inhibition Assay | 6.429154265 | Sanger |
SW684 | Growth Inhibition Assay | 157.170468 | Sanger |
SW756 | Growth Inhibition Assay | 7.78332792 | Sanger |
GP5d | Growth Inhibition Assay | 4.783875538 | Sanger |
JAR | Growth Inhibition Assay | 161.9714362 | Sanger |
KURAMOCHI | Growth Inhibition Assay | 67.24387929 | Sanger |
U-266 | Growth Inhibition Assay | 195.8703577 | Sanger |
No Data | Growth Inhibition Assay | 30 | Scientific Literature |
No Data | Growth Inhibition Assay | 0.0033 | Scientific Literature |
BT-20 | Growth Inhibition Assay | 8.260523804 | Sanger |
NCI-H1993 | Growth Inhibition Assay | 119.2735984 | Sanger |
TK-10 | Growth Inhibition Assay | 16.94729103 | Sanger |
ES6 | Growth Inhibition Assay | 94.7956953 | Sanger |
MHH-PREB-1 | Growth Inhibition Assay | 66.279457 | Sanger |
NB17 | Growth Inhibition Assay | 0.071237066 | Sanger |
H-EMC-SS | Growth Inhibition Assay | 4.318309473 | Sanger |
LU-135 | Growth Inhibition Assay | 0.18551881 | Sanger |
MKN45 | Growth Inhibition Assay | 140.2719446 | Sanger |
SK-N-FI | Growth Inhibition Assay | 48.0357728 | Sanger |
SK-NEP-1 | Growth Inhibition Assay | 0.072129151 | Sanger |
HPAF-II | Growth Inhibition Assay | 0.926281588 | Sanger |
YAPC | Growth Inhibition Assay | 83.23259184 | Sanger |
NB10 | Growth Inhibition Assay | 26.31165508 | Sanger |
NCI-H1770 | Growth Inhibition Assay | 6.208740144 | Sanger |
SK-MEL-24 | Growth Inhibition Assay | 20.14769722 | Sanger |
CAL-27 | Growth Inhibition Assay | 19.04872176 | Sanger |
NCI-N87 | Growth Inhibition Assay | 7.19292569 | Sanger |
SNB75 | Growth Inhibition Assay | 105.5159367 | Sanger |
HCC1806 | Growth Inhibition Assay | 7.260436856 | Sanger |
COLO-679 | Growth Inhibition Assay | 195.2008444 | Sanger |
SBC-5 | Growth Inhibition Assay | 244.638106 | Sanger |
DBTRG-05MG | Growth Inhibition Assay | 120.0390372 | Sanger |
NCI-H1793 | Growth Inhibition Assay | 134.2583596 | Sanger |
NCI-H526 | Growth Inhibition Assay | 11.50427839 | Sanger |
A-375 | Growth Inhibition Assay | 30.32428874 | Sanger |
ONS-76 | Growth Inhibition Assay | 107.0680914 | Sanger |
U-251 | Growth Inhibition Assay | 135.6106619 | Sanger |
SAOS-2 | Growth Inhibition Assay | 42.83690511 | Sanger |
EW-1 | Growth Inhibition Assay | 15.54618079 | Sanger |
HCC1187 | Growth Inhibition Assay | 74.96152636 | Sanger |
SK-OV-3 | Growth Inhibition Assay | 218.5673052 | Sanger |
KYSE-70 cell line | Growth Inhibition Assay | 8.077286606 | Sanger |
SK-LU-1 | Growth Inhibition Assay | 4.660888056 | Sanger |
SK-N-AS | Growth Inhibition Assay | 74.46006936 | Sanger |
KNS-42 | Growth Inhibition Assay | 12.99840945 | Sanger |
NCI-H630 | Growth Inhibition Assay | 5.994042145 | Sanger |
Capan-2 | Growth Inhibition Assay | 18.90780879 | Sanger |
NCI-H596 | Growth Inhibition Assay | 3.049973799 | Sanger |
Detroit 562 | Growth Inhibition Assay | 180.9596358 | Sanger |
Daoy | Growth Inhibition Assay | 96.30661423 | Sanger |
EFO-27 | Growth Inhibition Assay | 76.68821147 | Sanger |
DMS-114 | Growth Inhibition Assay | 66.9560879 | Sanger |
EPLC-272H | Growth Inhibition Assay | 9.37656977 | Sanger |
CAL-33 | Growth Inhibition Assay | 96.98564715 | Sanger |
COR-L105 | Growth Inhibition Assay | 16.65276053 | Sanger |
AU565 | Growth Inhibition Assay | 101.8597635 | Sanger |
CAL-51 | Growth Inhibition Assay | 167.4823546 | Sanger |
CAL-72 | Growth Inhibition Assay | 102.9183546 | Sanger |
ALL-PO | Growth Inhibition Assay | 0.219875896 | Sanger |
COR-L23 | Growth Inhibition Assay | 1.798739245 | Sanger |
Ca9-22 | Growth Inhibition Assay | 12.94508268 | Sanger |
OCUB-M | Growth Inhibition Assay | 57.13923451 | Sanger |
TGBC1TKB | Growth Inhibition Assay | 1.1415249 | Sanger |
LCLC-97TM1 | Growth Inhibition Assay | 223.5551188 | Sanger |
LK-2 | Growth Inhibition Assay | 4.112931358 | Sanger |
NCI-H1648 | Growth Inhibition Assay | 1.714176859 | Sanger |
SF539 | Growth Inhibition Assay | 173.9119262 | Sanger |
MDA-MB-157 | Growth Inhibition Assay | 4.887603004 | Sanger |
Hs-578-T | Growth Inhibition Assay | 189.9627499 | Sanger |
RMG-I | Growth Inhibition Assay | 0.494636564 | Sanger |
MDA-MB-175-VII | Growth Inhibition Assay | 18.92091644 | Sanger |
MSTO-211H | Growth Inhibition Assay | 181.6442311 | Sanger |
FaDu | Growth Inhibition Assay | 182.6831077 | Sanger |
RKO | Growth Inhibition Assay | 101.0576352 | Sanger |
TCC-SUP | Growth Inhibition Assay | 73.74535425 | Sanger |
LAN-6 | Growth Inhibition Assay | 4.451886772 | Sanger |
NH-12 | Growth Inhibition Assay | 0.107442334 | Sanger |
MC116 | Growth Inhibition Assay | 6.938967582 | Sanger |
NCI-H1437 | Growth Inhibition Assay | 128.7915235 | Sanger |
SCH | Growth Inhibition Assay | 72.74746063 | Sanger |
M059J | Growth Inhibition Assay | 12.77272451 | Sanger |
MOLT-16 | Growth Inhibition Assay | 0.652644962 | Sanger |
SCC-15 | Growth Inhibition Assay | 5.93662031 | Sanger |
NCI-H2405 | Growth Inhibition Assay | 2.827816898 | Sanger |
SCC-4 | Growth Inhibition Assay | 1.598869793 | Sanger |
697 | Growth Inhibition Assay | 0.108389398 | Sanger |
CFPAC-1 | Growth Inhibition Assay | 33.23325396 | Sanger |
A204 | Growth Inhibition Assay | 42.63877284 | Sanger |
FDC-P1 | Growth Inhibition Assay | 0.015 | Scientific Literature |
NCI-H1417 | Growth Inhibition Assay | 54.2 | Scientific Literature |
SK-MEL-2 | Growth Inhibition Assay | 11.76365861 | Sanger |
LNCaP-Clone-FGC | Growth Inhibition Assay | 105.5601571 | Sanger |
OE33 | Growth Inhibition Assay | 66.67406188 | Sanger |
HO-1-N-1 | Growth Inhibition Assay | 48.74448194 | Sanger |
TI-73 | Growth Inhibition Assay | 8.258508482 | Sanger |
SW620 | Growth Inhibition Assay | 4.570570349 | Sanger |
HLE | Growth Inhibition Assay | 44.08563533 | Sanger |
GOTO | Growth Inhibition Assay | 2.65377459 | Sanger |
OVCAR-3 | Growth Inhibition Assay | 7.330377388 | Sanger |
GT3TKB | Growth Inhibition Assay | 75.74458828 | Sanger |
NMC-G1 | Growth Inhibition Assay | 0.811206203 | Sanger |
TE-11 | Growth Inhibition Assay | 2.29473186 | Sanger |
NCI-H2029 | Growth Inhibition Assay | 4.941851211 | Sanger |
NCI-H661 | Growth Inhibition Assay | 26.47129663 | Sanger |
LOXIMVI | Growth Inhibition Assay | 86.99824969 | Sanger |
ZR-75-30 | Growth Inhibition Assay | 168.4553956 | Sanger |
KINGS-1 | Growth Inhibition Assay | 5.077438997 | Sanger |
KLE | Growth Inhibition Assay | 55.57464099 | Sanger |
SH-4 | Growth Inhibition Assay | 76.0193566 | Sanger |
RERF-LC-MS | Growth Inhibition Assay | 207.2939844 | Sanger |
TE-6 | Growth Inhibition Assay | 53.9451074 | Sanger |
NCI-H358 | Growth Inhibition Assay | 47.21496984 | Sanger |
LB831-BLC | Growth Inhibition Assay | 15.27665735 | Sanger |
NCI-H1693 | Growth Inhibition Assay | 28.69749969 | Sanger |
SJRH30 | Growth Inhibition Assay | 103.7751978 | Sanger |
SW1417 | Growth Inhibition Assay | 0.554383829 | Sanger |
IGROV-1 | Growth Inhibition Assay | 298.1298113 | Sanger |
SW13 | Growth Inhibition Assay | 96.19698344 | Sanger |
A498 | Growth Inhibition Assay | 182.33561 | Sanger |
ABC-1 | Growth Inhibition Assay | 17.81405941 | Sanger |
ES1 | Growth Inhibition Assay | 32.30616245 | Sanger |
HEC-1 | Growth Inhibition Assay | 10.3351737 | Sanger |
COLO-741 | Growth Inhibition Assay | 97.86735095 | Sanger |
COLO-824 | Growth Inhibition Assay | 1.01707921 | Sanger |
CP50-MEL-B | Growth Inhibition Assay | 9.757819855 | Sanger |
CaR-1 | Growth Inhibition Assay | 51.4784874 | Sanger |
BB30-HNC | Growth Inhibition Assay | 21.27445378 | Sanger |
8305C | Growth Inhibition Assay | 35.84152007 | Sanger |
769-P | Growth Inhibition Assay | 3.89510252 | Sanger |
KYSE-150 cell line | Growth Inhibition Assay | 91.030444 | Sanger |
NB14 | Growth Inhibition Assay | 1.137476259 | Sanger |
Ramos-2G6-4C10 | Growth Inhibition Assay | 1.736563222 | Sanger |
U-87 MG | Growth Inhibition Assay | 209.9623019 | Sanger |
HOP-92 | Growth Inhibition Assay | 2.587432316 | Sanger |
HOS | Growth Inhibition Assay | 67.20233541 | Sanger |
MKN1 | Growth Inhibition Assay | 83.81894031 | Sanger |
HSC-2 | Growth Inhibition Assay | 9.575502365 | Sanger |
UO-31 | Growth Inhibition Assay | 10.59082436 | Sanger |
NCI-H2291 | Growth Inhibition Assay | 11.54662285 | Sanger |
LoVo | Growth Inhibition Assay | 13.23131012 | Sanger |
HCC2157 | Growth Inhibition Assay | 1.194938835 | Sanger |
VM-CUB-1 | Growth Inhibition Assay | 21.35359266 | Sanger |
PSN1 | Growth Inhibition Assay | 41.17486511 | Sanger |
MPP-89 | Growth Inhibition Assay | 3.056660561 | Sanger |
PC-14 | Growth Inhibition Assay | 131.5726276 | Sanger |
SF126 | Growth Inhibition Assay | 8.838648674 | Sanger |
UACC-257 | Growth Inhibition Assay | 59.11761889 | Sanger |
UACC-62 | Growth Inhibition Assay | 141.1207631 | Sanger |
HCC1395 | Growth Inhibition Assay | 34.71858034 | Sanger |
OVCAR-5 | Growth Inhibition Assay | 10.6429319 | Sanger |
EW-3 | Growth Inhibition Assay | 0.080525289 | Sanger |
HCC2998 | Growth Inhibition Assay | 1.071353712 | Sanger |
HD-MY-Z | Growth Inhibition Assay | 5.239688238 | Sanger |
8505C | Growth Inhibition Assay | 4.542302309 | Sanger |
A3-KAW | Growth Inhibition Assay | 73.34856935 | Sanger |
A-431 | Growth Inhibition Assay | 18.41274338 | Sanger |
BT-549 | Growth Inhibition Assay | 96.69589977 | Sanger |
PFSK-1 | Growth Inhibition Assay | 6.05259436 | Sanger |
K5 | Growth Inhibition Assay | 45.94054222 | Sanger |
KYSE-510 | Growth Inhibition Assay | 71.88955622 | Sanger |
HT-1376 | Growth Inhibition Assay | 89.07440218 | Sanger |
HT-144 | Growth Inhibition Assay | 75.21690453 | Sanger |
NCI-H1304 | Growth Inhibition Assay | 0.46157395 | Sanger |
SN12C | Growth Inhibition Assay | 11.93547431 | Sanger |
T84 | Growth Inhibition Assay | 38.74090428 | Sanger |
HuO-3N1 | Growth Inhibition Assay | 2.487795557 | Sanger |
SF295 | Growth Inhibition Assay | 10.67038343 | Sanger |
MS-1 | Growth Inhibition Assay | 0.469334287 | Sanger |
GB-1 | Growth Inhibition Assay | 58.74664236 | Sanger |
DSH1 | Growth Inhibition Assay | 45.00326308 | Sanger |
ES4 | Growth Inhibition Assay | 1.34997625 | Sanger |
DoTc2-4510 | Growth Inhibition Assay | 3.014171501 | Sanger |
GCT | Growth Inhibition Assay | 7.569060868 | Sanger |
HEL | Growth Inhibition Assay | 1.310289362 | Sanger |
In Vivo Studies
- Navitoclax was formulated in 10% ethanol, 30% polyethylene glycol 400, and 60% Phosal 50 PG (a dispersion of 50% phosphatidylcholine in a propylene glycol/ethanol carrier) and administered orally by gavage. [2]
- ABT-263 was formulated in 10% ethanol, 30% polyethylene glycol 400, and 60% Phosal 50 PG. [3]
In vitro (25°C) | DMSO | 89 mg/mL (91.31 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5% DMSO+corn oil | 6 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 10.26 mL | 51.3 mL | 102.61 mL |
0.5 mM | 2.05 mL | 10.26 mL | 20.52 mL |
1 mM | 1.03 mL | 5.13 mL | 10.26 mL |
5 mM | 0.21 mL | 1.03 mL | 2.05 mL |
*The above data is based on the productmolecular weight 974.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10022 |
---|---|
Actions | Inhibitor |
CAS No. | 923564-51-6 |
Formula | C47H55ClF3N5O6S3 |
M. Wt | 974.6 |
Purity | >98% |
Synonyms | ABT263 |
SMILES | CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[[email protected]](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
- Tse C, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008 May 1;68(9):3421-8. doi: 10.1158/0008-5472.CAN-07-5836.
- Chen J, et al. The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo. Mol Cancer Ther. 2011 Dec;10(12):2340-9. doi: 10.1158/1535-7163.MCT-11-0415. Epub 2011 Sep 13.
- Shoemaker AR, et al. (2008) Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models. Clin Cancer Res 14(11):3268–3277.
- Santi Suryani, et al. Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts. Clin Cancer Res. 2014 Sep 1;20(17):4520-31. doi: 10.1158/1078-0432.CCR-14-0259. Epub 2014 Jul 10.
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