Mcl-1-PUMA Modulator-8

Catalog No.: A18369

Mcl-1-PUMA interface inhibitor

Mcl-1-PUMA Modulator-8

Mcl-1-PUMA Modulator-8 Chemical Structure

CAS NO. 678158-55-9

Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.41 mL 127.06 mL 254.12 mL
0.5 mM 5.08 mL 25.41 mL 50.82 mL
1 mM 2.54 mL 12.71 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

*The above data is based on the productmolecular weight 393.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18369
Actions Inhibitor
M. Wt 393.51
Formula C22H23N3O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 678158-55-9
Synonyms Mcl-1-PUMA modulator-8
SMILES O=C1N=C(N2CCN(CCO)CC2)S/C1=C\C3=CC=C(C4=CC=CC=C4)C=C3

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