Mcl-1-PUMA Modulator-8

Catalog No.: A18369

Mcl-1-PUMA interface inhibitor

Mcl-1-PUMA Modulator-8

Mcl-1-PUMA Modulator-8 Chemical Structure

CAS NO. 678158-55-9

Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.41 mL 127.06 mL 254.12 mL
0.5 mM 5.08 mL 25.41 mL 50.82 mL
1 mM 2.54 mL 12.71 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

*The above data is based on the productmolecular weight 393.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18369
Actions Inhibitor
CAS No. 678158-55-9
Formula C22H23N3O2S
M. Wt 393.51
Purity >98%
Synonyms Mcl-1-PUMA modulator-8
SMILES O=C1N=C(N2CCN(CCO)CC2)S/C1=C\C3=CC=C(C4=CC=CC=C4)C=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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