- Cat. No.
- A16192
CID5721353
CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor).
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- Cat. No.
- A16314
Apogossypolone (ApoG2)
Synonyms: ApoG2
Apogossypolone is a nonpeptidic small-molecule inhibitor of Bcl-2 with
In stock View Details -
- Cat. No.
- A16316
(+)-Apogossypol
Synonyms: Apogossypol; NSC736630
(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM.
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- Cat. No.
- A16323
(S)-Gossypol acetic acid
Synonyms: (S)-(+)-Gossypol acetic acid
(S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM).
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- Cat. No.
- A16380
Pyridoclax (MR-29072)
Synonyms: MR-29072
Pyridoclax is a potent Mcl-1 inhibitor with Kd value of 25 nM.
In stock View Details -
- Cat. No.
- A16880
AZD5991
AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay.
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- Cat. No.
- A17064
A-385358
A-385358 is an inhibitor of Bcl-XL that enhances the in vitro cytotoxic activity of numerous chemotherapeutic agents (paclitaxel, etoposide, cisplatin, and doxorubicin) in several tumor cell lines.
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- Cat. No.
- A17126
FX1
FX1 is an inhibitor of the transcription factor B cell lymphoma 6 (BCL6) with IC50 value of ~35 μM.
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- Cat. No.
- A17171
AZD-4320
AZD-4320 is a BH3 mimetic and dual Bcl-2/Bcl-XL inhibitor.
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- Cat. No.
- A17206
Maritoclax (Marinopyrrole A)
Synonyms: Marinopyrrole A
Marinopyrrole A, aslo known as Maritoclax, is a selective inhibitor of Mcl-1 with IC50 value of 10.1μM.
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- Cat. No.
- A18353
BT2
BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM.
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- Cat. No.
- A18356
S63845
S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1.
Out of stock
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- Cat. No.
- A18359
(R)-MIK665
(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special Mcl-1 inhibitor with an IC50 of 1.81 nM.
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- Cat. No.
- A18360
AMG-176
Synonyms: tapotoclax; tapotoclaxum.
AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a Ki of 0.13 nM.
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- Cat. No.
- A18361
S55746
Synonyms: BLC201
S55746 (BLC201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BLC201) has antitumor activity with low toxicity.
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- Cat. No.
- A18362
MIK665
Synonyms: S 64315
MIK665 (S-64315) is a special Mcl-1 inhibitor extracted from patent WO2016207225A1, compound Preparation 13, has an IC50 of 1.81 nM.
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- Cat. No.
- A18363
VU661013
VU661013 is a MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax Resistant Acute Myelogenous Leukemia.
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- Cat. No.
- A18364
ML311
Synonyms: EU-5346
ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction
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- Cat. No.
- A18366
Mcl1-IN-2
Synonyms: Mcl1-inhibitor-2
Mcl1-IN-2 is a selective Mcl-1 inhibitor.
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- Cat. No.
- A18368
Mcl1-IN-1
Synonyms: Mcl1-inhibitor-1
Mcl1-IN-1 is a potent and selective inhibitor of the apoptosis regulating proteins Mcl-1.
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- Cat. No.
- A18369
Mcl-1-PUMA Modulator-8
Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells.
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- Cat. No.
- A18372
Mcl1-IN-9
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.
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- Cat. No.
- A18373
PROTAC Mcl1 degrader-1
PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.
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- Cat. No.
- A18374
NPB
NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99, with an IC50 of 0.41 μM.
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- Cat. No.
- A18377
Mcl1-IN-11
Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.
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