A-1155463

Catalog No.: A16112

BCL-XL inhibitor

A-1155463

A-1155463 Chemical Structure

CAS NO. 1235034-55-5

A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
50 mg
$800.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805

Biological Activity

A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)
Targets
BCL-XL Bcl-w Bcl-2 Mcl-1
440 nM(Ki)
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.93 mL 74.65 mL 149.3 mL
0.5 mM 2.99 mL 14.93 mL 29.86 mL
1 mM 1.49 mL 7.47 mL 14.93 mL
5 mM 0.3 mL 1.49 mL 2.99 mL

*The above data is based on the productmolecular weight 669.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16112
Actions Inhibitor
M. Wt 669.79
Formula C35H32FN5O4S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1235034-55-5
Synonyms A 1155463, A1155463
SMILES O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O

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