A-1155463

Catalog No.: A16112
BCL-XL inhibitor
A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)
Grouped product items
Product Name Price Stock Qty
A-1155463 5mg
$100.00
In stock
A-1155463 10mg
$160.00
In stock
A-1155463 50mg
$520.00
In stock
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Adooq Products cited in reputable paper
Adooq's A-1155463 has been cited by 3 publications
  • Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
  • Daniel F R Boehmer, .et al. , Sci Immunol, 2021, Jul 16;6(61) PMID: 34272227
  • Chauhan D, .et al. , Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
  • Biological Activity
    Discription A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)
    Targets
    Target Value
    Product Information
    Catalog Num A16112
    Formula C35H32FN5O4S2
    Molecular Weight 669.79
    CAS Number 1235034-55-5
    SMILES O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O
    Synonyms A 1155463, A1155463
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 78 mg/mL (116.45 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 5 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 14.93 mL 74.65 mL 149.3 mL
    0.5 mM 2.99 mL 14.93 mL 29.86 mL
    1 mM 1.49 mL 7.47 mL 14.93 mL
    5 mM 0.3 mL 1.49 mL 2.99 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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