A-1155463

Catalog No.: A16112

BCL-XL inhibitor

A-1155463

A-1155463 Chemical Structure

CAS NO. 1235034-55-5

A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
50 mg
$800.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805

Biological Activity

A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)
Targets
BCL-XL Bcl-w Bcl-2 Mcl-1
440 nM(Ki)
In vitro (25°C) DMSO 78 mg/mL (116.45 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.93 mL 74.65 mL 149.3 mL
0.5 mM 2.99 mL 14.93 mL 29.86 mL
1 mM 1.49 mL 7.47 mL 14.93 mL
5 mM 0.3 mL 1.49 mL 2.99 mL

*The above data is based on the productmolecular weight 669.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16112
Actions Inhibitor
CAS No. 1235034-55-5
Formula C35H32FN5O4S2
M. Wt 669.79
Solubility DMSO
Purity >98%
Synonyms A 1155463, A1155463
SMILES O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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