DAPK

DAPK inhibitors target death-associated protein kinases, which couple stress signals to cell death. Death-associated protein kinase 1 (DAPK1) was cloned in 1995 from a screen for genes that mediate interferon-γ-induced cell death. DAPK1 is a calcium/calmodulin-regulated serine/threonine kinase with roles in apoptosis and autophagy. Its relatives include DAPK2, zipper-interacting protein kinase (ZIPK, also called DAPK3) and the DAPK-related apoptosis-inducing protein kinases (DRAK1, DRAK2). TC-DAPK6 and CK156 are listed as DAPK inhibitors, and HS38 acts on both DAPK1 and ZIPK. HS148 and HS94 are listed as DAPK3 inhibitors, while DRAK2-IN-1 targets DRAK2. PROTAC DAPK1 Degrader-1 is a proteolysis-targeting chimera (PROTAC) that induces DAPK1 degradation. DAPK Substrate Peptide serves as a phosphorylation substrate in kinase assays.