Fig. 1 · Structure
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Apostatin-1
TRADD Inhibitor
Apostatin-1 is a potent inhibitor of TRADD, effectively binding to the TRADD-N domain (KD = 2.17 μM) and disrupting its interactions with TRADD-C and TRAF2. This compound modulates the ubiquitination processes of RIPK1 and beclin 1, thereby blocking apoptosis. By activating autophagy, Apostatin-1 restores cellular homeostasis in cells exhibiting accumulated mutant proteins such as tau, α-synuclein, or huntingtin, making it a valuable tool for research in neurodegenerative diseases and apoptosis regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2559703-06-7 |
| Applications | TRADD Inhibitor |
| Formula | C19H27N3OS |
| Molecular Weight | 345.50 |
| Synonyms | Apt-1 |
| SMILES | O=C(NC1CCCCCC1)C(SC2=NCCN2C)C3=CC=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.