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Apremilast (CC 10004)

Apremilast (CC 10004)

Name: Apremilast (CC 10004)
SKU: A11289

Catalog No.: A11289

PDE4 Inhibitor

Apremilast (CC 10004) Chemical Structure

CAS NO. 608141-41-9

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $45.00 Special Price $36.00
10 mg	Regular Price: $65.00 Special Price $52.00
25 mg	Regular Price: $75.00 Special Price $60.00
200 mg	Regular Price: $300.00 Special Price $240.00
10mM * 1mL in DMSO	$60.00

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Biological Activity

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

Solubility *

In vitro (25°C)	DMSO	92 mg/mL (199.78 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	<1 mg/mL (<1 mM)
In vivo	0.5% CMC/0.25% Tween 80	30 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.72 mL	108.58 mL	217.16 mL
0.5 mM	4.34 mL	21.72 mL	43.43 mL
1 mM	2.17 mL	10.86 mL	21.72 mL
5 mM	0.43 mL	2.17 mL	4.34 mL

*The above data is based on the productmolecular weight 460.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11289
Actions	Inhibitor
M. Wt	460.5
Formula	C22H24N2O7S
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	608141-41-9
Synonyms	CC10004, CC-10004
SMILES	CCOC1=C(C=CC(=C1)[[email protected]@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC