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AR/BET protein degrader-1

Protein Degrader; PROTAC

AR/BET protein degrader-1 is a PROTAC designed to selectively target and degrade both the Androgen Receptor (AR) and BET proteins. This compound exhibits potent biological activity in modulating protein levels, making it a valuable tool for cancer research. It facilitates novel therapeutic strategies aimed at overcoming resistance mechanisms, thereby enhancing the understanding of cancer biology and treatment options.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2571123-81-2
Applications	Protein Degrader; PROTAC
Formula	C₄₃H₄₄N₆O₅
Molecular Weight	724.85
SMILES	CC1=NOC(C)=C1C2=CC=C(C)C(N(C[C@@H]3CC[C@@H](CNC4=CC(C(N(C5CCC(NC5=O)=O)C6=O)=O)=C6C=C4)CC3)C7=CC=C(C8(C#N)CC8)C=C7)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.