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AR Degrader-3

AR/ARV7 Degrader

AR Degrader-3 is an orally active molecular glue that targets the Androgen Receptor (AR) and its variant ARV7, inducing their degradation through the ubiquitin-proteasome pathway. By directly interacting with both the ligand-binding domain and the N-terminal domain of AR, it effectively suppresses the transcriptional activity of wild-type AR, AR mutants, and ARV7. This compound downregulates mRNA and protein levels of downstream AR target genes, providing a mechanism to overcome antiandrogen resistance associated with ARV7 and point mutations. Additionally, AR Degrader-3 promotes apoptosis in Enzalutamide-resistant cells through the elevation of cleaved caspase-3, making it a valuable tool in the research of castration-resistant prostate cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	1182011-65-9
Applications	AR/ARV7 Degrader
Formula	C₂₃H₂₁N₃O₄S
Molecular Weight	435.50
SMILES	CC1=NOC(C)=C1COC2=CC=C(C(NC3=NC(C4=CC=C(OC)C=C4)=CS3)=O)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.