Fig. 1 · Structure
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AR244555
MAS Inverse Agonist
AR244555 is a malate-aspartate shuttle (MAS) inverse agonist, exhibiting IC50 values of 186 nM in human inositol phosphatase and 348 nM in rat inositol phosphatase Gq coupling assays. This compound demonstrates cardioprotective effects, making it a valuable tool for research related to cardiovascular health and metabolic functions. Its selective modulation of MAS activity allows for exploration of its therapeutic potential in various heart-related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 858350-62-6 |
| Applications | MAS Inverse Agonist |
| Formula | C23H23ClF2N2O |
| Molecular Weight | 416.89 |
| SMILES | O=C(N1CC2(CCN(CCC=C)CC2)C3=C1C=CC(Cl)=C3)C4=C(F)C=CC=C4F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.