Fig. 1 · Structure
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AR453588 hydrochloride
Glucokinase Activator
AR453588 hydrochloride is a potent glucokinase activator with an EC50 of 42 nM. This compound exhibits significant anti-hyperglycemic activity, making it a valuable tool for research in diabetes and metabolic disorders. Its oral bioavailability enhances its potential for in vivo studies, facilitating exploration of glucokinase modulation in glucose metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1065606-97-4 |
| Applications | Glucokinase Activator |
| Formula | C25H26ClN7O2S2 |
| Molecular Weight | 556.10 |
| SMILES | CC(N1CCC(C2=NSC(NC3=NC=C(SC4=NC=CC=C4)C=C3OC5=CC=CN=C5C)=N2)CC1)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.