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Arf1-GEFs-IN-1

Arf1-GEFs Inhibitor

Arf1-GEFs-IN-1 is a selective inhibitor of ADP-ribosylation factor 1-guanine nucleotide exchange factors (Arf1-GEFs), showing an IC50 of 40.85 μM in CT26 cells. This compound primarily promotes tumor regression by enhancing anti-tumor immune responses rather than exerting direct cytotoxic effects. Additionally, Arf1-GEFs-IN-1 is effective in inducing CCL5 expression, demonstrating significant in vivo efficacy. It is a valuable tool for research in colon cancer and the exploration of immune modulation in tumor environments.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3091068-95-7
Applications	Arf1-GEFs Inhibitor
Formula	C₁₉H₁₈N₆S
Molecular Weight	362.45
SMILES	CN1CCC2=C(SC3=NC=NC(N/N=C/C4=CC5=C(NC=C5)C=C4)=C32)C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.