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Arfolitixorin sulfate

5-FU Moderator

Arfolitixorin sulfate is an active form of folate, specifically [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF), that acts as a moderator for 5-Fluorouracil (5-FU). This compound enhances the efficacy of 5-FU-based therapies and is particularly relevant in research focused on metastatic colorectal cancer. Its unique mechanism supports investigations into improving treatment outcomes and overcoming resistance in cancer models.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	149930-93-8
Applications	5-FU Moderator
Formula	C₂₀H₂₅N₇O₁₀S
Molecular Weight	555.52
SMILES	O=C(NC(N)=N1)C2=C1NC[C@@]3([H])N2CN(C4=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C4)C3.O=S(O)(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.