Fig. 1 · Structure
Documents & Downloads
Arfolitixorin
5-FU Moderator
Arfolitixorin is a potent modulator of 5-Fluorouracil (5-FU) and functions as an active form of folate, specifically [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). This compound plays a critical role in enhancing the efficacy of 5-FU chemotherapy, particularly in the treatment of metastatic colorectal cancer. Its mechanism of action makes it a valuable tool for research applications in cancer therapy, offering insights into folate metabolism and its implications in oncological treatments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 31690-11-6 |
| Applications | 5-FU Moderator |
| Formula | C20H23N7O6 |
| Molecular Weight | 457.44 |
| SMILES | O=C1NC(N)=NC2=C1N(CN(C3)C4=CC=C(C=C4)C(N[C@@H](CCC(O)=O)C(O)=O)=O)[C@]3([H])CN2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.