Fig. 1 · Structure
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Aristolactam I
AQP1 Inhibitor
Aristolactam I is an inhibitor of aquaporin 1 (AQP1), functioning as a metabolite of Aristolochic acid I derived from Aristolochia plants. This compound has demonstrated the ability to downregulate Twist1 expression while enhancing levels of E-cadherin and activating the TGF-β/Smad signaling pathway, which may contribute to its anticancer properties against breast cancer. Additionally, Aristolactam I is recognized for its nephrotoxic effects and is primarily utilized in research focused on breast cancer and renal conditions, such as renal interstitial fibrosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 13395-02-3 |
| Applications | AQP1 Inhibitor |
| Formula | C17H11NO4 |
| Molecular Weight | 293.27 |
| Synonyms | Aristololactam; Aristolactam |
| SMILES | O=C1NC2=C(C3=C4C(C(OC)=CC=C4)=C2)C1=CC5=C3OCO5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.