Apalutamide (ARN-509)

Catalog No.: A11923

Androgen Receptor inhibitor

Apalutamide (ARN-509) Chemical Structure

CAS NO. 956104-40-8

ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
25 mg
$240.00
50 mg
$350.00
10mM * 1mL in DMSO
$75.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes.
Targets
Androgen Receptor (Cell-free assay) GABAA receptor (Cell-free assay)
16 nM3 μM
In vitro (25°C) DMSO 18 mg/mL (37.7 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (10.47 mM)
In vivo 0.5% CMC, pH4.0 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.95 mL 104.73 mL 209.47 mL
0.5 mM 4.19 mL 20.95 mL 41.89 mL
1 mM 2.09 mL 10.47 mL 20.95 mL
5 mM 0.42 mL 2.09 mL 4.19 mL

*The above data is based on the productmolecular weight 477.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11923
Actions Inhibitor
M. Wt 477.4
Formula C21H15F4N5O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 956104-40-8
Synonyms ARN509
SMILES CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C4)C(F)(F)F)C#N)F

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