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- Fr谷d谷rique Mittler, .et al. High-Content Monitoring of Drug Effects in a 3D Spheroid Model, Front Oncol, 2017, 7: 293 PMID: 29322028
|Storage||at -20°C 3 years Powder|
|ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes.|
|Solubility (25°C) *||In vitro||DMSO||18 mg/mL (37.7 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||5 mg/mL (10.47 mM)|
|In vivo||0.5% CMC, pH4.0||14 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||20.95 mL||104.73 mL||209.47mL|
|0.5 mM||4.19 mL||20.95 mL||41.89 mL|
|1 mM||2.09 mL||10.47 mL||20.95 mL|
|5 mM||0.42 mL||2.09 mL||4.19 mL|
*The above data is based on the productmolecular weight 477.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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