Apalutamide (ARN-509)

Catalog No.: A11923
Androgen Receptor inhibitor
ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes.
Grouped product items
Product Name Price Stock Qty
ARN-509 5mg
$70.00
In stock
ARN-509 10mg
$120.00
In stock
ARN-509 25mg
$240.00
In stock
ARN-509 50mg
$350.00
In stock
ARN-509 10mM * 1mL in DMSO
$75.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's Apalutamide (ARN-509) has been cited by 1 publications
  • Frédérique Mittler, .et al. , Front Oncol, 2017, 7: 293 PMID: 29322028
  • Biological Activity
    Discription ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes.
    Targets
    Target Value
    Product Information
    Catalog Num A11923
    Formula C21H15F4N5O2S
    Molecular Weight 477.4
    CAS Number 956104-40-8
    SMILES CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C4)C(F)(F)F)C#N)F
    Synonyms ARN509
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 18 mg/mL (37.7 mM)
    Water Insoluble
    Ethanol 5 mg/mL (10.47 mM)
    In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 2 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.95 mL 104.73 mL 209.47 mL
    0.5 mM 4.19 mL 20.95 mL 41.89 mL
    1 mM 2.09 mL 10.47 mL 20.95 mL
    5 mM 0.42 mL 2.09 mL 4.19 mL
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