Fig. 1 · Structure
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ARN14494
SPT Inhibitor
ARN14494 is a selective inhibitor of serine palmitoyltransferase (SPT), exhibiting an IC50 of 27.3 nM. This compound demonstrates significant neuroprotective and anti-inflammatory effects, particularly in the context of Alzheimer's disease research. ARN14494 has been shown to safeguard neurons against β-amyloid 1-42-induced neurotoxicity through mechanisms such as antioxidant activity, anti-apoptotic effects, and the modulation of inflammatory responses. This makes ARN14494 a valuable tool for investigating therapeutic strategies for neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1037837-27-6 |
| Applications | SPT Inhibitor |
| Formula | C24H32N4O3 |
| Molecular Weight | 424.54 |
| SMILES | O=C(C1=CC2=C(N(C3CCN(CC(N4CC5C(CCC5)C4)=O)CC3)C(C2)=O)C=C1)NC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.